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Title:
CORANNULENE-INCORPORATED AIE NANODOTS WITH HIGHLY SUPPRESSED NONRADIATIVE DECAY FOR BOOSTED CANCER PHOTOTHERANOSTICS IN VIVO
Document Type and Number:
WIPO Patent Application WO/2019/161626
Kind Code:
A1
Abstract:
The present subject matter relates to fluorescent compounds that have aggregation-induced emission (AIE) characteristics and exhibit near infrared absorption. Compositions including the present compounds can include a corannulene-modified polyethylene glycol encapsulation matrix. The compositions can be in nanoparticle form. Encapsulating the AIE compounds within a corannulene matrix provides intraparticle rigidity and restricts intramolecular rotation of the encapsulated AIE compound, which results in enhanced fluorescence and ROS generation capacity of the compositions in vivo. Accordingly, the compositions can be useful in NIR imaging-guided cancer surgery and photodynamic cancer therapy.

Inventors:
TANG, Benzhong (Clear Water Bay Kowloon, Hong Kong, Kong, CN)
GU, Xinggui (Clear Water Bay Kowloon, Hong Kong, Kong, CN)
Application Number:
CN2018/091220
Publication Date:
August 29, 2019
Filing Date:
June 14, 2018
Export Citation:
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Assignee:
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (Clear Water Bay, Kowloon, Hong Kong, Kong, CN)
International Classes:
C09K11/06
Domestic Patent References:
WO2016070854A12016-05-12
Foreign References:
CN103194215A2013-07-10
Other References:
MOUSTAFA T. GABR ET AL.: "Synthesis and aggregation-induced emission properties of pyridine and pyridinium analogues of tetraphenylethylene", RSC ADVANCES, vol. 5, no. 110, 31 December 2015 (2015-12-31), pages 90226 - 90234, XP055633212
XINGGUI GU ET AL.: "Mitochondrion-Specifi c Live- Cell Bioprobe Operated in a Fluorescence Turn-On Manner and a Well-Designed Photoactivatable Mechanism", ADVANCED MATERIALS, vol. 27, no. 44, 7 October 2015 (2015-10-07), pages 7093 - 7100, XP055278311, doi:10.1002/adma.201503751
Attorney, Agent or Firm:
TEE & HOWE INTELLECTUAL PROPERTY ATTORNEYS (DING, Yeping10th Floor, Tower D, Minsheng Financial Center,28 Jianguomennei Avenue, Dongcheng District, Beijing 5, 100005, CN)
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