Title:
CORE-SHELL CROSSLINKED HYALURONIC ACID GEL PARTICLES, PRODUCTION METHOD FOR SAME, AND MEDICAL MATERIAL
Document Type and Number:
WIPO Patent Application WO/2015/005345
Kind Code:
A1
Abstract:
These core-shell crosslinked hyaluronic acid gel particles are core-shell crosslinked hyaluronic acid gel particles having higher equilibrium swelling ratio at the surface than at the center, an inflection point being present on the curve of change of the equilibrium swelling ratio plotted from the center to the surface, wherein the probe pushing force to a depth of 800 nm from the surface is 20 nN or less.
Inventors:
OHNO AKIO (JP)
HASHIMOTO MASAMICHI (JP)
NEMOTO HAREI (JP)
HARADA TAKAFUMI (JP)
FUJII KENJI (JP)
HASHIMOTO MASAMICHI (JP)
NEMOTO HAREI (JP)
HARADA TAKAFUMI (JP)
FUJII KENJI (JP)
Application Number:
PCT/JP2014/068195
Publication Date:
January 15, 2015
Filing Date:
July 08, 2014
Export Citation:
Assignee:
DENKI KAGAKU KOGYO KK (JP)
International Classes:
C08B37/08; A61K9/14; A61K31/728; A61K47/36; A61L15/16; A61L27/00; A61L31/00
Domestic Patent References:
| WO2012026468A1 | 2012-03-01 | |||
| WO2012026468A1 | 2012-03-01 |
Foreign References:
| JP2004181121A | 2004-07-02 | |||
| JPS63123392A | 1988-05-27 | |||
| JPH02234689A | 1990-09-17 |
Other References:
See also references of EP 3020733A4
CLIN. EXP. RHEUMATOL., vol. 20, 2002, pages 445 - 454
OSTEOARTHRITIS AND CARTILAGE, vol. 15, no. 5, 2007, pages 543 - 549
OSTEOARTHRITIS AND CARTILAGE, vol. 4, no. 2, 1996, pages 99 - 110
KANSETSU GEKA, vol. 15, no. 3, 1996, pages 92 - 98
YAKURI TO CHIRYO, vol. 23, 1995, pages 833 - 841
YAKURI TO CHIRYO, vol. 33, 2005, pages 303 - 312
SEIKEIGEKA KISO KAGAKU, vol. 9, 1982, pages 77 - 79
SEIKEIGEKAKISO KAGAKU, vol. 11, 1984, pages 125 - 127
ARTHRITIS & RHEUMATISM, vol. 48, no. 7, 2003, pages 1923 - 1929
CLIN. EXP. RHEUMATOL., vol. 20, 2002, pages 445 - 454
OSTEOARTHRITIS AND CARTILAGE, vol. 15, no. 5, 2007, pages 543 - 549
OSTEOARTHRITIS AND CARTILAGE, vol. 4, no. 2, 1996, pages 99 - 110
KANSETSU GEKA, vol. 15, no. 3, 1996, pages 92 - 98
YAKURI TO CHIRYO, vol. 23, 1995, pages 833 - 841
YAKURI TO CHIRYO, vol. 33, 2005, pages 303 - 312
SEIKEIGEKA KISO KAGAKU, vol. 9, 1982, pages 77 - 79
SEIKEIGEKAKISO KAGAKU, vol. 11, 1984, pages 125 - 127
ARTHRITIS & RHEUMATISM, vol. 48, no. 7, 2003, pages 1923 - 1929
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
Yoshiki Hasegawa (JP)
Yoshiki Hasegawa (JP)
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