Title:
CORNEAL ENDOTHELIAL CELL MARKER
Document Type and Number:
WIPO Patent Application WO/2016/035874
Kind Code:
A1
Abstract:
The present invention provides, inter alia, a molecular marker specifically expressed in corneal epithelial cells, a method for manufacturing corneal epithelial cells in which said marker is used, and a method for evaluating corneal epithelial cells. One or more molecules selected from the group consisting of ZP4, MRGPRX3, GRIP1, GRIP1R, HTR1D, and CLRN1 is utilized as a corneal-epithelial-cell-specific marker.
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Inventors:
NISHIDA KOHJI (JP)
TSUJIKAWA MOTOKAZU (JP)
HARA SUSUMU (JP)
KAWASAKI SATOSHI (JP)
YOSHIHARA MASAHITO (JP)
ITOH MASAYOSHI (JP)
KAWAJI HIDEYA (JP)
OHMIYA HIROKO (JP)
TSUJIKAWA MOTOKAZU (JP)
HARA SUSUMU (JP)
KAWASAKI SATOSHI (JP)
YOSHIHARA MASAHITO (JP)
ITOH MASAYOSHI (JP)
KAWAJI HIDEYA (JP)
OHMIYA HIROKO (JP)
Application Number:
PCT/JP2015/075164
Publication Date:
March 10, 2016
Filing Date:
September 04, 2015
Export Citation:
Assignee:
RIKEN (JP)
UNIV OSAKA (JP)
UNIV OSAKA (JP)
International Classes:
C12N5/10; C12N15/09; C12Q1/68; A61L27/00
Domestic Patent References:
| WO2015016371A1 | 2015-02-05 | |||
| WO2014007402A1 | 2014-01-09 | |||
| WO2013012087A1 | 2013-01-24 |
Other References:
YOSHIHARA, M. ET AL.: "Discovery of Molecular Markers to Discriminate Corneal Endothelial Cells in the Human Body", PLOS ONE, vol. 10, no. 3, 25 March 2015 (2015-03-25), pages e0117581, XP055416395
MASAHITO YOSHIHARA ET AL.: "Shinki Kakumaku Naihi Saibo Tokuiteki Marker no Dotei", THE 37TH ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN KOEN YOSHISHU, 7 November 2014 (2014-11-07), pages 2P-0115, XP009500876
HIROATSU HIRANO ET AL.: "Baiyo Kakumaku Naihi Saibo no Hinshitsu Kikaku ni Okeru Saibo Hyomen Marker no Yuyosei", REGENERATIVE MEDICINE, vol. 13, no. 278, 2014, pages 1 - 098, XP009500860, ISSN: 1347-7919
SUGURU NAKAGAWA ET AL.: "Jisedai Sequencer o Mochiita Morateki Hatsugen Kaiseki ni yoru Kakumaku Naihi no Marker Idenshi Tansaku", JOURNAL OF JAPANESE OPHTHALMOLOGICAL SOCIETY, vol. 117, no. issue, 378, 2013, pages 181, XP009500846, ISSN: 0029-0203
SHIN HATO ET AL.: "Kakumaku Jisshitsu Kansaibo kara Kakumaku Naihi Saibo eno Bunka Yudo", REGENERATIVE MEDICINE, vol. 10, no. 163, 2011, pages O-17 - 1, XP008173359, ISSN: 1347-7919
ASAKO YAMAMIZU ET AL.: "Kakumaku Naihi Saibo Tokuiteki Saibo Hyomen Marker no Dotei", REGENERATIVE MEDICINE, September 2010 (2010-09-01), pages P-081, XP009500844, ISSN: 1347-7919
CHEN, Y. ET AL.: "Identification of novel molecular markers through transcriptomic analysis in human fetal and adult corneal endothelial cells", HUMAN MOLECULAR GENETICS, vol. 22, no. 7, 2013, pages 1271 - 1279, XP055294770, ISSN: 1460-2083
See also references of EP 3190181A4
MASAHITO YOSHIHARA ET AL.: "Shinki Kakumaku Naihi Saibo Tokuiteki Marker no Dotei", THE 37TH ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN KOEN YOSHISHU, 7 November 2014 (2014-11-07), pages 2P-0115, XP009500876
HIROATSU HIRANO ET AL.: "Baiyo Kakumaku Naihi Saibo no Hinshitsu Kikaku ni Okeru Saibo Hyomen Marker no Yuyosei", REGENERATIVE MEDICINE, vol. 13, no. 278, 2014, pages 1 - 098, XP009500860, ISSN: 1347-7919
SUGURU NAKAGAWA ET AL.: "Jisedai Sequencer o Mochiita Morateki Hatsugen Kaiseki ni yoru Kakumaku Naihi no Marker Idenshi Tansaku", JOURNAL OF JAPANESE OPHTHALMOLOGICAL SOCIETY, vol. 117, no. issue, 378, 2013, pages 181, XP009500846, ISSN: 0029-0203
SHIN HATO ET AL.: "Kakumaku Jisshitsu Kansaibo kara Kakumaku Naihi Saibo eno Bunka Yudo", REGENERATIVE MEDICINE, vol. 10, no. 163, 2011, pages O-17 - 1, XP008173359, ISSN: 1347-7919
ASAKO YAMAMIZU ET AL.: "Kakumaku Naihi Saibo Tokuiteki Saibo Hyomen Marker no Dotei", REGENERATIVE MEDICINE, September 2010 (2010-09-01), pages P-081, XP009500844, ISSN: 1347-7919
CHEN, Y. ET AL.: "Identification of novel molecular markers through transcriptomic analysis in human fetal and adult corneal endothelial cells", HUMAN MOLECULAR GENETICS, vol. 22, no. 7, 2013, pages 1271 - 1279, XP055294770, ISSN: 1460-2083
See also references of EP 3190181A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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