Title:
CORONAVIRUS PROPAGATION METHOD
Document Type and Number:
WIPO Patent Application WO/2022/034882
Kind Code:
A1
Abstract:
Provided is a method for efficiently propagating a coronavirus, which is a material for a vaccine, in a host. A method for propagating a coronavirus in a host, said method comprising a step for inhibiting the migration of Bax in host cells to the mitochondrial inner membrane.
Inventors:
ONISHI SHINTARO (JP)
HIRAMA YUI (JP)
MORI TAKUYA (JP)
HIRAMA YUI (JP)
MORI TAKUYA (JP)
Application Number:
PCT/JP2021/029525
Publication Date:
February 17, 2022
Filing Date:
August 10, 2021
Export Citation:
Assignee:
KAO CORP (JP)
International Classes:
C12N7/00; A61K31/166; A61K35/76; A61K39/215; A61P31/12; A61P37/04; C07K7/00
Domestic Patent References:
| WO2020166524A1 | 2020-08-20 |
Foreign References:
| JP2005320276A | 2005-11-17 |
Other References:
REN LILI, YANG RENQUAN, GUO LI, QU JIANGUO, WANG JIANWEI, HUNG TAO: "Apoptosis Induced by the SARS-Associated Coronavirus in Vero Cells Is Replication-Dependent and Involves Caspase", DNA AND CELL BIOLOGY, vol. 24, no. 8, 1 August 2005 (2005-08-01), US , pages 496 - 502, XP055900256, ISSN: 1044-5498, DOI: 10.1089/dna.2005.24.496
CUCONATI ANDREA, DEGENHARDT KURT, SUNDARARAJAN RAMYA, ANSCHEL ALAN, WHITE EILEEN: "Bak and Bax Function To Limit Adenovirus Replication through Apoptosis Induction", JOURNAL OF VIROLOGY, vol. 76, no. 9, 1 May 2002 (2002-05-01), US , pages 4547 - 4558, XP055900259, ISSN: 0022-538X, DOI: 10.1128/JVI.76.9.4547-4558.2002
GARNER THOMAS P.; AMGALAN DULGUUN; REYNA DENIS E.; LI SHENG; KITSIS RICHARD N.; GAVATHIOTIS EVRIPIDIS: "Small-molecule allosteric inhibitors of BAX", NATURE CHEMICAL BIOLOGY, vol. 15, no. 4, 4 February 2019 (2019-02-04), New York, pages 322 - 330, XP036739140, ISSN: 1552-4450, DOI: 10.1038/s41589-018-0223-0
CUCONATI ANDREA, DEGENHARDT KURT, SUNDARARAJAN RAMYA, ANSCHEL ALAN, WHITE EILEEN: "Bak and Bax Function To Limit Adenovirus Replication through Apoptosis Induction", JOURNAL OF VIROLOGY, vol. 76, no. 9, 1 May 2002 (2002-05-01), US , pages 4547 - 4558, XP055900259, ISSN: 0022-538X, DOI: 10.1128/JVI.76.9.4547-4558.2002
GARNER THOMAS P.; AMGALAN DULGUUN; REYNA DENIS E.; LI SHENG; KITSIS RICHARD N.; GAVATHIOTIS EVRIPIDIS: "Small-molecule allosteric inhibitors of BAX", NATURE CHEMICAL BIOLOGY, vol. 15, no. 4, 4 February 2019 (2019-02-04), New York, pages 322 - 330, XP036739140, ISSN: 1552-4450, DOI: 10.1038/s41589-018-0223-0
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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