Title:
CORYNEBACTERIUM GLUTAMICUM MUTANT STRAIN HAVING IMPROVED L-GLUTAMIC ACID PRODUCTION ABILITY, AND METHOD FOR PRODUCING L-GLUTAMIC ACID USING SAME
Document Type and Number:
WIPO Patent Application WO/2021/162189
Kind Code:
A1
Abstract:
The present invention relates to a Corynebacterium glutamicum mutant strain having an improved L-glutamic acid production ability, a method for producing same, and a method for producing L-glutamic acid using same, wherein the Corynebacterium glutamicum mutant strain enhances the excretion of glutamic acid by introducing a Corynebacterium sp.-derived mechanosensory ion channel gene, thereby improving the production yield of L-glutamic acid, and therefore, it is possible to more effectively produce L-glutamic acid by using the mutant strain.
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Inventors:
LEE YOUNG JU (KR)
KIM BONG KI (KR)
CHOI MIN JIN (KR)
PARK SEOK HYUN (KR)
HAN JAE CHUN (KR)
KIM BONG KI (KR)
CHOI MIN JIN (KR)
PARK SEOK HYUN (KR)
HAN JAE CHUN (KR)
Application Number:
PCT/KR2020/011406
Publication Date:
August 19, 2021
Filing Date:
August 26, 2020
Export Citation:
Assignee:
DAESANG CORP (KR)
International Classes:
C12N15/77; C12N15/67; C12P13/14
Domestic Patent References:
| WO2006070944A2 | 2006-07-06 |
Foreign References:
| KR100824457B1 | 2008-04-22 | |||
| US6852516B2 | 2005-02-08 | |||
| US6962805B2 | 2005-11-08 |
Other References:
DATABASE Nucleotide Genbank; ANONYMOUS: "Corynebacterium callunae DSM 20147, complete genome", XP055836860, retrieved from NCBI
NAKAYAMA YOSHITAKA; HASHIMOTO KEN-ICHI; SAWADA YASUYUKI; SOKABE MASAHIRO; KAWASAKI HISASHI; MARTINAC BORIS: "Corynebacterium glutamicummechanosensitive channels: towards unpuzzling “glutamate efflux” for amino acid production", BIOPHYSICAL REVIEWS, SPRINGER, DE, vol. 10, no. 5, 12 September 2018 (2018-09-12), DE, pages 1359 - 1369, XP036634180, ISSN: 1867-2450, DOI: 10.1007/s12551-018-0452-1
NAKAMURA J, HIRANO S, ITO H, WACHI M.: "Mutations of the Corynebacterium glutamicum NCgl1221 gene, encoding a mechanosensitive channel homolog, induce l-glutamic acid production", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 73, no. 14, 1 July 2007 (2007-07-01), US, pages 4491 - 4498, XP002691368, ISSN: 0099-2240, DOI: 10.1128/AEM.02446-06
VAN DER REST ET AL., APPL. MICROBIOL. BIOTECHNOL., vol. 52, 1999, pages 541 - 545
"Manual of Methods for General Bacteriology", 1981, AMERICAN SOCIETY FOR BACTERIOLOGY
BACTERIOL., vol. 179, 1997, pages 6228 - 6237
GENE, vol. 145, 1994, pages 69 - 73
See also references of EP 4105331A4
NAKAYAMA YOSHITAKA; HASHIMOTO KEN-ICHI; SAWADA YASUYUKI; SOKABE MASAHIRO; KAWASAKI HISASHI; MARTINAC BORIS: "Corynebacterium glutamicummechanosensitive channels: towards unpuzzling “glutamate efflux” for amino acid production", BIOPHYSICAL REVIEWS, SPRINGER, DE, vol. 10, no. 5, 12 September 2018 (2018-09-12), DE, pages 1359 - 1369, XP036634180, ISSN: 1867-2450, DOI: 10.1007/s12551-018-0452-1
NAKAMURA J, HIRANO S, ITO H, WACHI M.: "Mutations of the Corynebacterium glutamicum NCgl1221 gene, encoding a mechanosensitive channel homolog, induce l-glutamic acid production", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 73, no. 14, 1 July 2007 (2007-07-01), US, pages 4491 - 4498, XP002691368, ISSN: 0099-2240, DOI: 10.1128/AEM.02446-06
VAN DER REST ET AL., APPL. MICROBIOL. BIOTECHNOL., vol. 52, 1999, pages 541 - 545
"Manual of Methods for General Bacteriology", 1981, AMERICAN SOCIETY FOR BACTERIOLOGY
BACTERIOL., vol. 179, 1997, pages 6228 - 6237
GENE, vol. 145, 1994, pages 69 - 73
See also references of EP 4105331A4
Attorney, Agent or Firm:
PCR INTELLECTUAL PROPERTY LAW FIRM (KR)
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