COTTON-LIKE FIBER SCAFFOLD AS WELL AS PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

WIPO Patent Application WO/2020/151261

A1

A cotton-like fiber scaffold as well as a preparation method therefor and an application thereof. A cotton-like fiber scaffold having a compression ratio as high as 45%, recovery rate as high as 80% and quite high adaptability may be prepared by using an electrostatic spinning method to blend and spin polylactic acid and bioactive materials such as bioglass, beta-tricalcium phosphate or calcium sulfate. The prepared cotton-like fiber scaffold has smaller fiber diameter, higher flexibility and higher porosity and specific surface area, and may provide more attachment points for osteoblasts and shorten rehabilitation time. The scaffold further has excellent biological activity, biocompatibility and biodegradability. An inorganic part in the scaffold may be degraded in vivo to generate elements essential for osteogenesis, and an inorganic part polylactic acid therein has good biodegradability and biocompatibility and may be degraded to generate lactic acid, and then the lactic acid is converted into carbon dioxide and water under the action of enzyme. The cotton-like fiber scaffold has no toxic side effects on a human body.

LI ZIQIAO (CN)
ZHOU JIE (CN)
XU JIALIN (CN)

PCT/CN2019/110974

July 30, 2020

October 14, 2019

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AILEX TECH GROUP CO LTD (CN)
ZHEJIANG AILEX MEDICAL CO LTD (CN)

D04H1/4382; A61L27/44; D01D5/00

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CN105126175A	2015-12-09
CN102499997A	2012-06-20
GB2484319A	2012-04-11
US20060204539A1	2006-09-14

BEYOND ATTORNEYS AT LAW (CN)

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