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Patent Searching and Data


Title:
COVALENT CHEMICAL INDUCERS OF PROTEIN DIMERIZATION AND THEIR USES IN HIGH THROUGHPUT BINDING SCREENS
Document Type and Number:
WIPO Patent Application WO2002059272
Kind Code:
A3
Abstract:
Described are compounds having the formula: H1-Y-H2 where H1 is a substrate capable of selectively binding to a first receptor; where H2 is a substrate capable of selectively binding to and selectively forming a covalent bond with a second receptor; and wherein Y is a molety providing a covalent linkage between H1 and H2, which may be present or absent, and when absent, H1 is covalently linked to H2. Also described are uses of the compounds for in vivo screening of compounds are proteins.

Inventors:
CORNISH VIRGINIA W (US)
Application Number:
PCT/US2002/002199
Publication Date:
February 20, 2003
Filing Date:
January 24, 2002
Export Citation:
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Assignee:
UNIV COLUMBIA (US)
CORNISH VIRGINIA W (US)
International Classes:
C07D501/00; C12N15/10; C12N15/62; (IPC1-7): C12Q1/68; A61K39/395; C07D501/00; C07K16/00
Domestic Patent References:
WO2001053355A12001-07-26
Other References:
LICITRA ET AL.: "A three-hybrid system for detecting small ligand-protein receptor interactions", PROC. NATL. ACAD. SCI. USA, vol. 93, November 1996 (1996-11-01), pages 12817 - 12821, XP002939143
LIN ET AL.: "Dexamethasone-methotrexate: an efficient chemical inducer of protein dimerization in vivo", J. AM. CHEM. SOC., vol. 122, no. 17, 2000, pages 4247 - 4248, XP002955788
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