Title:
COXSACKIE VIRUS B FOR TREATING TUMORS
Document Type and Number:
WIPO Patent Application WO/2019/201192
Kind Code:
A1
Abstract:
Provided are Coxsackie virus CVB1 or a modified form thereof, or a genomic sequence or cDNA sequence comprising CVB1 or the modified form thereof, or a nucleic acid molecule of a complement sequence of the genomic sequence or cDNA sequence, the use of same for treating tumors in subjects including humans, and the use of same in the preparation of a pharmaceutical composition for treating tumors in subjects including humans. Also provided is a method for treating tumors, comprising administering CVB1 or the modified form thereof, or the genomic sequence or cDNA sequence comprising CVB1 or the modified form thereof, or the nucleic acid molecule of the complement sequence of the genomic sequence or cDNA sequence to a subject in need thereof.
Inventors:
CHENG TONG (CN)
WANG WEI (CN)
YE XIANGZHONG (CN)
FU WENKUN (CN)
PAN DEQUAN (CN)
ZHANG JUN (CN)
XIA NINGSHAO (CN)
WANG WEI (CN)
YE XIANGZHONG (CN)
FU WENKUN (CN)
PAN DEQUAN (CN)
ZHANG JUN (CN)
XIA NINGSHAO (CN)
Application Number:
PCT/CN2019/082608
Publication Date:
October 24, 2019
Filing Date:
April 15, 2019
Export Citation:
Assignee:
XI AMEN UNIV (CN)
YANG SHENG TANG CO LTD (CN)
YANG SHENG TANG CO LTD (CN)
International Classes:
A61P35/00; C12N7/01; A61P35/02; A61P35/04
Domestic Patent References:
| WO2008103755A1 | 2008-08-28 |
Foreign References:
| CN109568350A | 2019-04-05 | |||
| US20180085411A1 | 2018-03-29 | |||
| CN103981152A | 2014-08-13 | |||
| CN101065144A | 2007-10-31 | |||
| US20160143969A1 | 2016-05-26 |
Other References:
DOBRIKOVA ET AL., MOL THER, vol. 16, no. 11, 2008, pages 1865 - 1872
SHAFREN ET AL., INT J CANCER, vol. 115, no. 2, 2005, pages 320 - 328
HALEY ET AL., J MOL MED (BERL, vol. 87, no. 4, 2009, pages 385 - 399
RINEHART ET AL., J VIROL, vol. 71, no. 5, 1997, pages 3986 - 3991
"GenBank", Database accession no. KY286529.1
RUIZ AJ: "MicroRNAs and oncolytic viruses", J]. CURR OPIN VIROL, vol. 13, 2015, pages 40 - 48
ARDOLINO MHSU JRAULET D H: "Cytokine treatment in cancer immunotherapy", J]. ONCOTARGET, vol. 6, no. 23, 2015, pages 19346 - 19347
CANDOLFI MKING GDMUHAMMAD AG ET AL.: "Evaluation of proapototic transgenes to use in combination with Flt3L in an immune-stimulatory gene therapy approach for Glioblastoma multiforme (GBM", J]. FASEB J, vol. 22, 2008
NOLAN ESAVAS PPOLICHENI AN ET AL.: "Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer", J]. SCIENCE TRANS MED, vol. 9, 2017, pages eaa14922
ROSCA EVKOSKIMAKI JERIVERA CG ET AL.: "Anti-angiogenic peptides for cancer therapeutics", J]. CURR PHARM BIOTECHNOL, vol. 12, no. 8, 2011, pages 1101 - 1116
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
PLUCKTHUN: "The Pharmacology of Monoclonal Antibodies", vol. 113, 1994, SPRINGER-VERLAG, pages: 269 - 315
NEEDLEMAN ET AL., J. MOL. BIOL., vol. 48, 1970, pages 444 - 453
E. MEYERSW. MILLER, COMPUT. APPL. BIOSCI., vol. 4, 1988, pages 11 - 17
FM AUSUBEL ET AL.: "Short Protocols in Molecular Biology", 1995, JOHN WILEY & SONS, INC.
MERRILLGROMEIER, J VIROL, vol. 80, no. 14, 2006, pages 6936 - 6942
NEPLIOUEVA ET AL., PLOS ONE, vol. 5, no. 7, 2010, pages e11710
DOBRIKOV ET AL., MOL CELL BIOL, vol. 31, no. 14, 2011, pages 2947 - 2959
DOBRIKOV ET AL., MOL CELL BIOL, vol. 33, no. 5, 2013, pages 937 - 946
BAOHONG ZHANG ET AL., DEVELOPMENTAL BIOLOGY, vol. 302, 1 February 2007 (2007-02-01), pages 1 - 12
HOU WHYANG LSLI SX ET AL., VIRUS RES, vol. 205, 2015, pages 165 - 168
YIN H ET AL., NAT REV GENET, vol. 15, no. 8, August 2014 (2014-08-01), pages 541 - 55
RILEY MKVERMERRIS W, NANOMATERIALS (BASEL, vol. 7, no. 5, 28 April 2017 (2017-04-28), pages E94
J. SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
YANG ET AL., CLIN VACCINE IMMUNOL, vol. 21, no. 3, 2014, pages 312 - 320
HOU ET AL., HUMAN, VIRUS RES, vol. 205, 2015, pages 41 - 44
HADAC E MKELLY E JRUSSELL S J, MOL THE, vol. 19, no. 6, 2011, pages 1041 - 1047
SHAFREN ET AL., INT J CANCER, vol. 115, no. 2, 2005, pages 320 - 328
HALEY ET AL., J MOL MED (BERL, vol. 87, no. 4, 2009, pages 385 - 399
RINEHART ET AL., J VIROL, vol. 71, no. 5, 1997, pages 3986 - 3991
"GenBank", Database accession no. KY286529.1
RUIZ AJ: "MicroRNAs and oncolytic viruses", J]. CURR OPIN VIROL, vol. 13, 2015, pages 40 - 48
ARDOLINO MHSU JRAULET D H: "Cytokine treatment in cancer immunotherapy", J]. ONCOTARGET, vol. 6, no. 23, 2015, pages 19346 - 19347
CANDOLFI MKING GDMUHAMMAD AG ET AL.: "Evaluation of proapototic transgenes to use in combination with Flt3L in an immune-stimulatory gene therapy approach for Glioblastoma multiforme (GBM", J]. FASEB J, vol. 22, 2008
NOLAN ESAVAS PPOLICHENI AN ET AL.: "Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer", J]. SCIENCE TRANS MED, vol. 9, 2017, pages eaa14922
ROSCA EVKOSKIMAKI JERIVERA CG ET AL.: "Anti-angiogenic peptides for cancer therapeutics", J]. CURR PHARM BIOTECHNOL, vol. 12, no. 8, 2011, pages 1101 - 1116
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
PLUCKTHUN: "The Pharmacology of Monoclonal Antibodies", vol. 113, 1994, SPRINGER-VERLAG, pages: 269 - 315
NEEDLEMAN ET AL., J. MOL. BIOL., vol. 48, 1970, pages 444 - 453
E. MEYERSW. MILLER, COMPUT. APPL. BIOSCI., vol. 4, 1988, pages 11 - 17
FM AUSUBEL ET AL.: "Short Protocols in Molecular Biology", 1995, JOHN WILEY & SONS, INC.
MERRILLGROMEIER, J VIROL, vol. 80, no. 14, 2006, pages 6936 - 6942
NEPLIOUEVA ET AL., PLOS ONE, vol. 5, no. 7, 2010, pages e11710
DOBRIKOV ET AL., MOL CELL BIOL, vol. 31, no. 14, 2011, pages 2947 - 2959
DOBRIKOV ET AL., MOL CELL BIOL, vol. 33, no. 5, 2013, pages 937 - 946
BAOHONG ZHANG ET AL., DEVELOPMENTAL BIOLOGY, vol. 302, 1 February 2007 (2007-02-01), pages 1 - 12
HOU WHYANG LSLI SX ET AL., VIRUS RES, vol. 205, 2015, pages 165 - 168
YIN H ET AL., NAT REV GENET, vol. 15, no. 8, August 2014 (2014-08-01), pages 541 - 55
RILEY MKVERMERRIS W, NANOMATERIALS (BASEL, vol. 7, no. 5, 28 April 2017 (2017-04-28), pages E94
J. SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
YANG ET AL., CLIN VACCINE IMMUNOL, vol. 21, no. 3, 2014, pages 312 - 320
HOU ET AL., HUMAN, VIRUS RES, vol. 205, 2015, pages 41 - 44
HADAC E MKELLY E JRUSSELL S J, MOL THE, vol. 19, no. 6, 2011, pages 1041 - 1047
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
Download PDF: