Title:
CREATINE PRODRUGS, COMPOSITIONS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/106284
Kind Code:
A3
Abstract:
The invention describes membrane permeable creatine prodrugs, pharmaceutical compositions comprising membrane permeable creatine prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and genetic disorders affecting the creatine kinase system comprising administering creatine prodrugs or pharmaceutical compositions thereof. The invention also describes treating a genetic disease affecting the creatine kinase system, such as, for example, a creatine transporter disorder or a creatine synthesis disorder comprising administering creatine prodrugs or pharmaceutical compositions thereof.
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Inventors:
BRUBAKER WILLIAM F (US)
Application Number:
PCT/US2015/067283
Publication Date:
October 13, 2016
Filing Date:
December 22, 2015
Export Citation:
Assignee:
FARMINGTON PHARMA DEV (US)
International Classes:
C07D273/04; A61K31/4245; A61K31/5395; A61K31/551; A61P25/00; A61P25/28; C07D271/07; C07D273/06
Domestic Patent References:
| WO2014018570A1 | 2014-01-30 | |||
| WO2013043580A2 | 2013-03-28 | |||
| WO2010005692A2 | 2010-01-14 | |||
| WO2009143630A1 | 2009-12-03 |
Foreign References:
| US20080051371A1 | 2008-02-28 |
Other References:
See also references of EP 3237391A4
Attorney, Agent or Firm:
WU, Nan et al. (1299 Pennsylvania Avenue NW Suite 70, Washington District of Columbia, US)
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