Title:
CRF ANTAGONISTS AND HETEROBICYCLIC COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2005/026126
Kind Code:
A1
Abstract:
CRF antagonists containing as the active ingredient compounds represented by the general formula (I): (I) wherein A is an optionally substituted 5- or 6-membered monocycle; B is a 5- to 7-membered monocyclic unsaturated heterocycle which may additionally contain one or two heteroatoms and which may be additionally substituted; W1 and W2 are each carbon or nitrogen; Z is NR3, oxygen, optionally oxidized sulfur, or CR4R5; R1 is optionally substituted, alkyl, alkenyl, or alkynyl, optionally protected amino, optionally protected hydroxyl, optionally protected SH, S(O)nR6, COR7, or an optionally substituted cyclic group; and R2 is an unsaturated cyclic group which may be substituted.
Inventors:
NAKAI HISAO (JP)
SAITO TETSUJI (JP)
OBITSU TETSUO (JP)
MINAMOTO CHIAKI (JP)
YOSHIDA MAYUKI (JP)
KISHI AKIHIRO (JP)
KATSUMATA SEISHI (JP)
KATAYAMA HIDEO (JP)
SAITO TETSUJI (JP)
OBITSU TETSUO (JP)
MINAMOTO CHIAKI (JP)
YOSHIDA MAYUKI (JP)
KISHI AKIHIRO (JP)
KATSUMATA SEISHI (JP)
KATAYAMA HIDEO (JP)
Application Number:
PCT/JP2004/013386
Publication Date:
March 24, 2005
Filing Date:
September 08, 2004
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
NAKAI HISAO (JP)
SAITO TETSUJI (JP)
OBITSU TETSUO (JP)
MINAMOTO CHIAKI (JP)
YOSHIDA MAYUKI (JP)
KISHI AKIHIRO (JP)
KATSUMATA SEISHI (JP)
KATAYAMA HIDEO (JP)
NAKAI HISAO (JP)
SAITO TETSUJI (JP)
OBITSU TETSUO (JP)
MINAMOTO CHIAKI (JP)
YOSHIDA MAYUKI (JP)
KISHI AKIHIRO (JP)
KATSUMATA SEISHI (JP)
KATAYAMA HIDEO (JP)
International Classes:
C07D221/04; C07D239/70; C07D487/04; C07D491/04; C07D491/048; (IPC1-7): C07D221/04; C07D239/16; C07D239/70; C07D491/048; C07D487/04; C07D513/04; A61K31/435; A61K31/505; A61K31/517; A61K31/519; A61K31/53
Foreign References:
| JPH0466571A | 1992-03-02 | |||
| JPS62132862A | 1987-06-16 | |||
| JPH04300883A | 1992-10-23 | |||
| JPH0748359A | 1995-02-21 |
Other References:
SMIRNOVA T.A. ET AL.: "Synthesis and pharmacological activity of 2-arylamino-5,6- tri(tetra)methyleneisonicotinic acid amides", PHARMACEUTICAL CHEMISTRY JOURNAL, vol. 33, no. 4, 2000, pages 194 - 195, XP002983498
See also references of EP 1666468A4
See also references of EP 1666468A4
Attorney, Agent or Firm:
Ohie, Kunihisa (Selva-Ningyocho 6F 14-6, Nihonbashi-Ningyocho 2-chom, Chuo-ku Tokyo, JP)
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