Title:
CROCINS COMPOUNDS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/185900
Kind Code:
A1
Abstract:
Provided are a series of crocins compounds and related pharmacological application thereof in prevention and treatment of Alzheimer's disease. The series of crocins compounds are obtained by taking the Chinese herb, namely Gardenia jasminoides Ellis, as a raw material and separating same by means of various methods. The compounds playing a role in preventing oxidative injury caused by hydrogen peroxide (H2O2) and excitatory amino acid injury caused by L-glutamic acid are screened out by in-vitro cell experiments. The results show that the crocins compounds have good effect in preventing cell injury caused by H2O2 and L-glutamic acid. The compounds have good effect in preventing and treating Alzheimer's disease due to the fact that significant rise of oxidative stress and excitatory amino acid is a key factor for nerve injury in Alzheimer's disease, and have broad development and application prospect.
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Inventors:
YAO XINSHENG (CN)
YU YANG (CN)
ZHANG DAN (CN)
NI YANG (CN)
BAO XIUQI (CN)
LI LIN (CN)
ZANG CAIXIA (CN)
GAO HAO (CN)
ZHENG YUANPENG (CN)
YU YANG (CN)
ZHANG DAN (CN)
NI YANG (CN)
BAO XIUQI (CN)
LI LIN (CN)
ZANG CAIXIA (CN)
GAO HAO (CN)
ZHENG YUANPENG (CN)
Application Number:
PCT/CN2017/076911
Publication Date:
November 02, 2017
Filing Date:
March 16, 2017
Export Citation:
Assignee:
UNIV JINAN (CN)
International Classes:
C07H13/04; A61K31/7024; A61P25/00; A61P25/28; C07H1/08; C07H13/06
Foreign References:
| CN1123663A | 1996-06-05 | |||
| CN102802636A | 2012-11-28 |
Other References:
TARANTILIS, P.A. ET AL.: "Determination of Saffron (Crocus sativus L.) Components in Crude Plant Extract Using High-performance Liquid Chromatography-UV-visible Photodiode-array Detection-mass Spectrometry", J. CHROMATOGR. A, vol. 699, no. 1, 31 December 1995 (1995-12-31), pages 107 - 118, XP 004022999
PAPANDREOU, M.A. ET AL.: "Inhibitory Activity on Amyloid-O Aggregation and Antioxidant Properties of Crocus sativus Stigmas Extract and Its Crocin Constituents", J. AGIRC. FOODCHEM., vol. 54, no. 23, 20 October 2006 (2006-10-20), pages 8762 - 8768, XP 009095513
YU , YANG: "Studies on Chemical Constituents of Gardenia Jasminoides for the Treatment of Alzheimer's Diseases", MEDICINE & PUBLIC HEALTH, CHINA DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, 15 August 2015 (2015-08-15), pages 1 - 3, XP009510794, Retrieved from the Internet
PAPANDREOU, M.A. ET AL.: "Inhibitory Activity on Amyloid-O Aggregation and Antioxidant Properties of Crocus sativus Stigmas Extract and Its Crocin Constituents", J. AGIRC. FOODCHEM., vol. 54, no. 23, 20 October 2006 (2006-10-20), pages 8762 - 8768, XP 009095513
YU , YANG: "Studies on Chemical Constituents of Gardenia Jasminoides for the Treatment of Alzheimer's Diseases", MEDICINE & PUBLIC HEALTH, CHINA DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, 15 August 2015 (2015-08-15), pages 1 - 3, XP009510794, Retrieved from the Internet
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
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