CROSS-LINKING AGENT RESIDUE-FREE COLLAGEN FILLER FOR INJECTION AND PREPARATION METHOD THEREFOR

WIPO Patent Application WO/2023/143392

A1

Disclosed are a cross-linking agent residue-free collagen filler for injection and a preparation method therefor. The collagen filler for injection comprises collagen cross-linked by carbodiimide (EDC), water for injection and an excipient, and is free of cross-linking agent residues, wherein the collagen is a macromolecular I-type recombinant collagen, and is composed of multiple repetitions of a short amino acid sequence from natural human I-type collagen as a repeating unit, the number of repetitions is 75-110 times, and the short amino acid sequence is GAPGAPGSQGAPGLQ. The I-type recombinant collagen has good stability. In the method for preparing the cross-linking agent residue-free collagen filler for injection, EDC is used for cross-linking the collagen, the used cross-linking agent has a low concentration, the operation is simple and easy, the cross-linking degree can be increased by means of secondary cross-linking, and EDC can be basically completely removed only by means of a simple cleaning operation using a phosphoric acid buffer solution after the cross-linking reaction is completed.

FAN DAIDI (CN)
GU JUAN (CN)
SHI JINGJING (CN)
DUAN ZHIGUANG (CN)
XU RU (CN)
YAN JIANYA (CN)
LIU LIN (CN)

PCT/CN2023/073215

August 03, 2023

January 19, 2023

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SHAANXI GIANT BIOTECHNOLOGY CO LTD (CN)

A61L27/24; A61L27/50; A61L27/58; C07K14/78

CN114404668A	2022-04-29
CN107812244A	2018-03-20
CN102657584A	2012-09-12
CN102906107A	2013-01-30
CN103333508A	2013-10-02
CN112334168A	2021-02-05
US20110207671A1	2011-08-25

BEIJING TANGSONG IP FIRM (CN)

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