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Patent Searching and Data


Title:
CROWN ETHER DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2005016874
Kind Code:
A3
Abstract:
The invention describes crown ether chelators, including crown ethers having the formula (A) or (B); and aza-substituted and thia-substituted analogs thereof. These crown ethers may be substituted by a dye moiety, a chemically reactive group, a conjugated substance, or a combination thereof. Chelators that are substituted by fluorescent dyes are particularly useful as indicators for metal cations, particularly Na<+> and K<+> ions, and particularly where binding of the target ion results in a change in the fluorescence properties of the indicator that can be correlated with the ion concentration. Methods are provided for utilizing reactive groups on the chelators for conjugation to dyes, lipids and polymers and methods for enhancing entry of the indicators into living cells.

Inventors:
GEE KYLE (US)
MARTIN VLADIMIR (US)
Application Number:
US0324662W
Publication Date:
November 17, 2005
Filing Date:
August 04, 2003
Export Citation:
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Assignee:
MOLECULAR PROBES, INC.
GEE, KYLE
MARTIN, VLADIMIR
International Classes:
C07D273/00; C07H21/00; C09B57/10; C09B69/00; G01N33/58; G01N33/84; (IPC1-7): G01N33/53
Foreign References:
US20020164616A12002-11-07
US20040096978A12004-05-20
US6124135A2000-09-26
US5773227A1998-06-30
US5405975A1995-04-11
US5134232A1992-07-28
US5096831A1992-03-17
US4843158A1989-06-27
Other References:
See also references of EP 1660884A2
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