Title:
CRUSHED CELLS AND COMPOSITION THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/173163
Kind Code:
A1
Abstract:
Crushed cells are obtained by culturing gram-negative bacteria and physically crushing the gram-negative bacterial cells, contain all components that contain immunity-activating components of the cells, and contain LPS having a molecular weight of 20,000 or less as an active ingredient. These crushed cells are effective as a health food, drug, skin care product, bath salt, prophylactic feed and growth-promoting feed additive for crustaceans and shellfish, fish, domestic poultry, livestock, and pets, and make it possible to provide a natural immunity-activating material derived from gram-negative bacterial cells having a prophylactic effect and growth-promoting effect,
and inexpensive, practical microbial crushed cells and a composition thereof.
Inventors:
SOMA GEN-ICHIRO (JP)
INAGAWA HIROYUKI (JP)
KOHCHI CHIE (JP)
INAGAWA HIROYUKI (JP)
KOHCHI CHIE (JP)
Application Number:
PCT/JP2012/065173
Publication Date:
December 20, 2012
Filing Date:
June 14, 2012
Export Citation:
Assignee:
SOMA GEN-ICHIRO (JP)
INAGAWA HIROYUKI (JP)
KOHCHI CHIE (JP)
BIOMEDICAL RES GROUP INC (JP)
INAGAWA HIROYUKI (JP)
KOHCHI CHIE (JP)
BIOMEDICAL RES GROUP INC (JP)
International Classes:
C12N1/20; A01N63/20; A23L33/135; A61K8/99; A61K35/74; A61P3/00; A61P3/02; A61P25/00; A61P25/22; A61P31/00; A61P35/00; A61P37/02; A61P37/04; A61P37/08; A61Q19/00; C05F11/08
Domestic Patent References:
| WO2007061102A1 | 2007-05-31 |
Foreign References:
| JP2004262773A | 2004-09-24 | |||
| JP2526733B2 | 1996-08-21 | |||
| JP4043533B2 | 2008-02-06 | |||
| JPH06217712A | 1994-08-09 | |||
| JP2526733B2 | 1996-08-21 | |||
| JP2011132743A | 2011-07-07 |
Other References:
CHIE KOCHI ET AL.: "Development of lipopolysaccharide material characterized by safety and enhancement of innate immunity", THE FOOD INDUSTRY, 30 December 2010 (2010-12-30), pages 52 - 61, XP008168225
HIROYUKI INAGAWA ET AL.: "Kenko Shikosei Shokuhin Sozai to shite no Gram Inseikin Lipopolysaccharide (LPS) no Kanosei", NEW FOOD INDUSTRY, vol. 51, no. 5, 2009, pages 37 - 42, XP008167957
HIROYUKI INAGAWA ET AL.: "New Approach of Lipopolysaccharide Derived from Dietary-Experienced Gram-Negative Bacteria (IP-PA1) Based on the Macrophage-Network", JAPANESE JOURNAL OF COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol. 4, no. 2, 2007, pages 79 - 90, XP008168121
SAIBO HAKAI, SHIN SEIKAGAKU KOZA 17 BISEIBUTSU JIKKENHO, 1992, pages 173 - 178, XP008168821
TAKERU NAKAMOTO ET AL.: "Treatments for the activating macrophages that reduces surgical stress and postoperative mortalities from bacterial infections and tumor metastases", IN VIVO, vol. 21, 2007, pages 357 - 364
R. HERICH; MLEVKUT: "Lactic acid bacteria, probiotics and immune system", VET. MED.-CZECH, vol. 47, 2002, pages 169 - 180
ELISA OVINTINI 1; MARCELA S MEDINA 1: "Host Immunity in the protective response to nasal immunization with a pneumococcal antigen associated to live and heat-killed Lactobacillus casei", BMC IMMUNOLOGY, vol. 12, 2011, pages 46, XP021091870, DOI: doi:10.1186/1471-2172-12-46
ADAMS CA, NUTRITION RESEARCH REVIEW, vol. 23, no. 1, 2010, pages 37 - 46
ADRIANA A PEDROSO; MARGIE D LEE, POULTRY INFORMED PROFESSIONAL, vol. 114, 2010, pages 1 - 4
WIKIPEDIA: "Toll-like receptor"
TAKAMITSU T ET AL.: "Effect of a cell preparation of Enterococcus faecalis strain EC-12 on digesta flow and recovery from constipation in a pig model and human subjects", MICROBIAL ECOLOGY IN HEALTH AND DISEASE, vol. 17, 2005, pages 107 - 113, XP008167676, DOI: doi:10.1080/08910600510044507
"Wikipedia", article "Gram staining"
"Wikipedia", article "Peptidoglycan"
"Wikipedia", article "Lipopolysaccharide"
"Wikipedia", article "Lipid A"
TAKASHI NISHIZAWA ET AL.: "Homeostasis as regulated by activated macrophage. I. Lipopolysaccharide (LPS) from wheat flour: Isolation, purification and some biological activities", CHEM. PHARM. BULL., vol. 40, 1992, pages 479 - 483
See also references of EP 2722386A4
HIROYUKI INAGAWA ET AL.: "Kenko Shikosei Shokuhin Sozai to shite no Gram Inseikin Lipopolysaccharide (LPS) no Kanosei", NEW FOOD INDUSTRY, vol. 51, no. 5, 2009, pages 37 - 42, XP008167957
HIROYUKI INAGAWA ET AL.: "New Approach of Lipopolysaccharide Derived from Dietary-Experienced Gram-Negative Bacteria (IP-PA1) Based on the Macrophage-Network", JAPANESE JOURNAL OF COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol. 4, no. 2, 2007, pages 79 - 90, XP008168121
SAIBO HAKAI, SHIN SEIKAGAKU KOZA 17 BISEIBUTSU JIKKENHO, 1992, pages 173 - 178, XP008168821
TAKERU NAKAMOTO ET AL.: "Treatments for the activating macrophages that reduces surgical stress and postoperative mortalities from bacterial infections and tumor metastases", IN VIVO, vol. 21, 2007, pages 357 - 364
R. HERICH; MLEVKUT: "Lactic acid bacteria, probiotics and immune system", VET. MED.-CZECH, vol. 47, 2002, pages 169 - 180
ELISA OVINTINI 1; MARCELA S MEDINA 1: "Host Immunity in the protective response to nasal immunization with a pneumococcal antigen associated to live and heat-killed Lactobacillus casei", BMC IMMUNOLOGY, vol. 12, 2011, pages 46, XP021091870, DOI: doi:10.1186/1471-2172-12-46
ADAMS CA, NUTRITION RESEARCH REVIEW, vol. 23, no. 1, 2010, pages 37 - 46
ADRIANA A PEDROSO; MARGIE D LEE, POULTRY INFORMED PROFESSIONAL, vol. 114, 2010, pages 1 - 4
WIKIPEDIA: "Toll-like receptor"
TAKAMITSU T ET AL.: "Effect of a cell preparation of Enterococcus faecalis strain EC-12 on digesta flow and recovery from constipation in a pig model and human subjects", MICROBIAL ECOLOGY IN HEALTH AND DISEASE, vol. 17, 2005, pages 107 - 113, XP008167676, DOI: doi:10.1080/08910600510044507
"Wikipedia", article "Gram staining"
"Wikipedia", article "Peptidoglycan"
"Wikipedia", article "Lipopolysaccharide"
"Wikipedia", article "Lipid A"
TAKASHI NISHIZAWA ET AL.: "Homeostasis as regulated by activated macrophage. I. Lipopolysaccharide (LPS) from wheat flour: Isolation, purification and some biological activities", CHEM. PHARM. BULL., vol. 40, 1992, pages 479 - 483
See also references of EP 2722386A4
Attorney, Agent or Firm:
NAKAMURA KAZUO (JP)
Kazuo Nakamura (JP)
Kazuo Nakamura (JP)
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Claims: