Title:
CRYPTOTANSHINONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN RESISTING NEUROINFLAMMATION AND NEUROPROTECTION
Document Type and Number:
WIPO Patent Application WO/2021/164155
Kind Code:
A1
Abstract:
The present invention relates to a cryptotanshinone derivative, a preparation method therefor and an application thereof in resisting neuroinflammation and neuroprotection. The cryptotanshinone derivative has the structure as shown in formula I: (I). The present invention provides three novel anti-neuroinflammatory and neuroprotective agents, characterized in: using the cryptotanshinone derivative having the structure as shown in formula I or salts thereof in the present invention as an effective component for preventing or treating neurodegenerative disorders related to neuroinflammation such as Alzheimer's disease and parkinsonism.
Inventors:
WANG CHANGYUN (CN)
SHAO CHANGLUN (CN)
WU JINGSHUAI (CN)
GUAN HUASHI (CN)
SHAO CHANGLUN (CN)
WU JINGSHUAI (CN)
GUAN HUASHI (CN)
Application Number:
PCT/CN2020/096101
Publication Date:
August 26, 2021
Filing Date:
June 15, 2020
Export Citation:
Assignee:
OCEAN UNIV CHINA (CN)
International Classes:
C07J73/00; A61K31/58; A61P25/00; A61P25/16; A61P25/28; A61P29/00; C12P17/04; C12R1/645
Foreign References:
| CN111269283A | 2020-06-12 | |||
| CN102603861A | 2012-07-25 |
Other References:
SUN JIANG-HAO, YANG MIN, MA XIAO-CHI, KANG JIE, HAN JIAN, GUO DE-AN: "Microbial biotransformation of cryptotanshinone by Cunninghamella elegans and its application for metabolite identification in rat bile", JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, GORDON AND BREACH, CHUR, CH, vol. 11, no. 6, 1 June 2009 (2009-06-01), CH, pages 482 - 489, XP055838567, ISSN: 1028-6020, DOI: 10.1080/10286020902877754
MAIONE FRANCESCO; PICCOLO MARIALUISA; DE VITA SIMONA; CHINI MARIA GIOVANNA; CRISTIANO CLAUDIA; DE CARO CARMEN; LIPPIELLO PELLEGRIN: "Down regulation of pro-inflammatory pathways by tanshinone IIA and cryptotanshinone in a non-genetic mouse model of Alzheimer’s disease", PHARMACOLOGICAL RESEARCH., ACADEMIC PRESS, LONDON., GB, vol. 129, 20 November 2017 (2017-11-20), GB, pages 482 - 490, XP085353387, ISSN: 1043-6618, DOI: 10.1016/j.phrs.2017.11.018
GUANGHONG CUI, DUAN LIXIN, JIN BAOLONG, QIAN JUN, XUE ZHEYONG, SHEN GUOAN, SNYDER JOHN, HUGH, SONG JINGYUAN, CHEN SHILIN, HUANG LU: "Functional divergence of diterpene syntheses in the medicinal plant Salvia miltiorrhiza", PLANT PHYSIOLOGY, AMERICAN SOCIETY OF PLANT PHYSIOLOGISTS, ROCKVILLE, MD, USA, vol. 169, 1 November 2015 (2015-11-01), Rockville, Md, USA, pages 1607 - 1618, XP055292937, ISSN: 0032-0889, DOI: 10.1104/pp.15.00695
ZHU BOFENG, LI XIAOQIN;WU JINGSHUAI;YOU SONG;ZHOU LINA: "The Primary and Second Hydroxylation of Sclareol by Cunninghamella Elegans AS3.2028", SHENYANG YAOKE DAXUE XUEBAO - JOURNAL OF SHENYANG PHARMACEUTICAL UNIVERSITY., CHINESE ELECTRONIC PERIODICAL SERVICES, LIAONING, CN, vol. 35, no. 4, 1 April 2018 (2018-04-01), LIAONING, CN, pages 325 - 328, XP055838571, ISSN: 1006-2858, DOI: 10.14066 /j.cnki.cn21-1349 /r.2018.04.013
MAIONE FRANCESCO; PICCOLO MARIALUISA; DE VITA SIMONA; CHINI MARIA GIOVANNA; CRISTIANO CLAUDIA; DE CARO CARMEN; LIPPIELLO PELLEGRIN: "Down regulation of pro-inflammatory pathways by tanshinone IIA and cryptotanshinone in a non-genetic mouse model of Alzheimer’s disease", PHARMACOLOGICAL RESEARCH., ACADEMIC PRESS, LONDON., GB, vol. 129, 20 November 2017 (2017-11-20), GB, pages 482 - 490, XP085353387, ISSN: 1043-6618, DOI: 10.1016/j.phrs.2017.11.018
GUANGHONG CUI, DUAN LIXIN, JIN BAOLONG, QIAN JUN, XUE ZHEYONG, SHEN GUOAN, SNYDER JOHN, HUGH, SONG JINGYUAN, CHEN SHILIN, HUANG LU: "Functional divergence of diterpene syntheses in the medicinal plant Salvia miltiorrhiza", PLANT PHYSIOLOGY, AMERICAN SOCIETY OF PLANT PHYSIOLOGISTS, ROCKVILLE, MD, USA, vol. 169, 1 November 2015 (2015-11-01), Rockville, Md, USA, pages 1607 - 1618, XP055292937, ISSN: 0032-0889, DOI: 10.1104/pp.15.00695
ZHU BOFENG, LI XIAOQIN;WU JINGSHUAI;YOU SONG;ZHOU LINA: "The Primary and Second Hydroxylation of Sclareol by Cunninghamella Elegans AS3.2028", SHENYANG YAOKE DAXUE XUEBAO - JOURNAL OF SHENYANG PHARMACEUTICAL UNIVERSITY., CHINESE ELECTRONIC PERIODICAL SERVICES, LIAONING, CN, vol. 35, no. 4, 1 April 2018 (2018-04-01), LIAONING, CN, pages 325 - 328, XP055838571, ISSN: 1006-2858, DOI: 10.14066 /j.cnki.cn21-1349 /r.2018.04.013
Attorney, Agent or Firm:
BEIJING WITAL PATENT AGENCY CO., LTD (CN)
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