Title:
CRYSTAL OF 3'-SIALYLLACTOSE SODIUM SALT N-HYDRATE, AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2017/195743
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: a crystal of 3'-sialyllactose (also referred to as "3SL", hereinafter), which is easy to handle and has high storage stability under ambient-temperature and high-temperature conditions; and a method for producing the crystal. The present invention relates to: a crystal of a 3SL sodium salt n-hydrate (wherein n represents an arbitrary numerical value of 0 to 9, and the 3SL sodium salt n-hydrate refers to as "3SL sodium salt anhydride" when n is 0); and a method for producing the crystal.
Inventors:
YOKOI TOMOYA (JP)
NAGANO HIROSHI (JP)
MASE KIKUE (JP)
ABE MASAHIRO (JP)
NAGANO HIROSHI (JP)
MASE KIKUE (JP)
ABE MASAHIRO (JP)
Application Number:
PCT/JP2017/017422
Publication Date:
November 16, 2017
Filing Date:
May 08, 2017
Export Citation:
Assignee:
KYOWA HAKKO BIO CO LTD (JP)
International Classes:
C07H3/06
Domestic Patent References:
| WO1998048817A1 | 1998-11-05 | |||
| WO2017086443A1 | 2017-05-26 | |||
| WO2014069625A1 | 2014-05-08 |
Foreign References:
| JPH10513437A | 1998-12-22 | |||
| JP2012522761A | 2012-09-27 | |||
| JPH08252403A | 1996-10-01 | |||
| JPH10513437A | 1998-12-22 |
Other References:
ITO,YUKISHIGE: "Highly stereoselective glycosylation of sialic acid aided by stereocontrolling auxiliaries", TETRAHEDRON, vol. 46, no. 1, 1990, pages 89 - 102, XP055547361
RENCUROSI, ANNA ET AL.: "Human milk oligosaccharides: an enzymatic protection step simplifies the synthesis of 3'- and 6'-O-sialyllactose and their analogues", CARBOHYDRATE RESEARCH, vol. 337, no. 6, 15 March 2002 (2002-03-15), pages 473 - 483, XP004343543
CARBOHYDRATE RESEARCH., vol. 337, 2002, pages 473
APPLY MICROBIOL BIOTECHNOL., vol. 53, 2000, pages 257
ACTA CRYST., vol. A64, 2008, pages 112
J. PHARM. SCI., vol. 64, no. 8, 1975, pages 1269 - 1288
See also references of EP 3456727A4
RENCUROSI, ANNA ET AL.: "Human milk oligosaccharides: an enzymatic protection step simplifies the synthesis of 3'- and 6'-O-sialyllactose and their analogues", CARBOHYDRATE RESEARCH, vol. 337, no. 6, 15 March 2002 (2002-03-15), pages 473 - 483, XP004343543
CARBOHYDRATE RESEARCH., vol. 337, 2002, pages 473
APPLY MICROBIOL BIOTECHNOL., vol. 53, 2000, pages 257
ACTA CRYST., vol. A64, 2008, pages 112
J. PHARM. SCI., vol. 64, no. 8, 1975, pages 1269 - 1288
See also references of EP 3456727A4
Attorney, Agent or Firm:
EIKOH PATENT FIRM, P.C. (JP)
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