Title:
CRYSTAL OF BENDAMUSTINE HYDROCHLORIDE AND PREPARATION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/091373
Kind Code:
A1
Abstract:
The present invention relates to a crystal of bendamustine hydrochloride and a preparation method thereof. The crystal of the present invention has excellent flowability and can be better used in production and clinical treatment.
Inventors:
WANG LIKUN (CN)
DU ZHENXING (CN)
GAO MENG (CN)
DU ZHENXING (CN)
GAO MENG (CN)
Application Number:
PCT/CN2018/114148
Publication Date:
May 16, 2019
Filing Date:
November 06, 2018
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
International Classes:
A61K31/4184; A61P35/00; C07D235/16
Foreign References:
| CN101980698A | 2011-02-23 |
Other References:
CHEN, LEI ET AL.: "Optimization of synthetic process of bendamustin", CHINA PHARMACIST, vol. 16, no. 2, 31 December 2013 (2013-12-31), pages 251
YIN, XIN: "Synthesis and Structure Modification of Vorinostat and Bendamustine Hydrochloride", MEDICINE & PUBLIC HEALTH, CHINA MASTER'S THESES FULL-TEXT DATABASE, 15 June 2012 (2012-06-15)
YIN, XIN: "Synthesis and Structure Modification of Vorinostat and Bendamustine Hydrochloride", MEDICINE & PUBLIC HEALTH, CHINA MASTER'S THESES FULL-TEXT DATABASE, 15 June 2012 (2012-06-15)
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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