Title:
CRYSTAL OF COMPOUND AS C-MET KINASE INHIBITOR AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/166012
Kind Code:
A1
Abstract:
The present application falls within the field of medicinal chemistry, relates to the crystal of a compound as a c-Met kinase inhibitor, and specifically relates to the crystal of N-(4-((7-((1-(cyclopentylamino)cyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and a preparation method therefor, a crystalline composition thereof, and a pharmaceutical composition thereof, as well as the use of the crystal for treating diseases associated with the inhibition of growth factor receptor protein tyrosine kinase activity. The crystal of the present application has excellent properties in at least one of the following aspects: pharmacokinetics, bioavailability, hygroscopicity, stability, solubility, purity, ease of preparation, etc.
Inventors:
GONG FENG (CN)
HUANG TICONG (CN)
ZANG HAISHAN (CN)
ZHANG SHIBO (CN)
ZHAO RUI (CN)
LIU FEI (CN)
HUANG TICONG (CN)
ZANG HAISHAN (CN)
ZHANG SHIBO (CN)
ZHAO RUI (CN)
LIU FEI (CN)
Application Number:
PCT/CN2019/076683
Publication Date:
September 06, 2019
Filing Date:
March 01, 2019
Export Citation:
Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)
International Classes:
C07D215/22; A61K31/47; A61P29/00; A61P35/00; A61P37/06
Domestic Patent References:
| WO2012034055A2 | 2012-03-15 |
Foreign References:
| CN105153028A | 2015-12-16 |
Other References:
SONNENBERG ET AL., J. CELL BIOL., vol. 123, 1993, pages 223 - 235
MATSUMATO ET AL., CRIT. REV. ONCOG., vol. 3, 1992, pages 27 - 54
STOKER ET AL., NATURE, vol. 327, 1987, pages 239 - 242
"Guidelines for Drug Moisture Test", CHINESE PHARMACOPOEIA, 2015
See also references of EP 3766870A4
MATSUMATO ET AL., CRIT. REV. ONCOG., vol. 3, 1992, pages 27 - 54
STOKER ET AL., NATURE, vol. 327, 1987, pages 239 - 242
"Guidelines for Drug Moisture Test", CHINESE PHARMACOPOEIA, 2015
See also references of EP 3766870A4
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
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