Title:
CRYSTAL OF COMPOUND HAVING JAK-INHIBITING ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2017/150477
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a compound having an excellent JAK1-inhibiting activity. The compound according to the present invention has a JAK1-inhibiting activity, and therefore has an immunesuppressing effect, an anti-inflammatory effect, a proliferation-inhibiting effect and the like, and is useful for the treatment of diseases such as rheumatoid arthritis, inflammatory bowel disease, psoriasis, angiitis, bronchial asthma, chronic obstructive pulmonary disease, eosinophilic sinusitis and rhinopolypus.
Inventors:
HIGUCHI FUMI (JP)
Application Number:
PCT/JP2017/007594
Publication Date:
September 08, 2017
Filing Date:
February 28, 2017
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD (JP)
International Classes:
C07D513/04; A61K31/506; A61P1/04; A61P3/10; A61P5/14; A61P7/00; A61P9/00; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/04; A61P17/06; A61P17/14; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P27/04; A61P27/14; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; A61P43/00
Domestic Patent References:
| WO2013025628A1 | 2013-02-21 | |||
| WO2016035814A1 | 2016-03-10 | |||
| WO2010149769A1 | 2010-12-29 | |||
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Foreign References:
| JP2009513571A | 2009-04-02 | |||
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| JP2011136925A | 2011-07-14 | |||
| US4918073A | 1990-04-17 |
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VAINCHENKER ET AL., SEMIN. CELL DEV. BIOL., vol. 19, 2008, pages 385 - 393
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ZHANG ET AL., ARCH. DERMATOL. RES., vol. 307, 2015, pages 319 - 331
NISHIMOTO ET AL., J. RHEUMATOL., vol. 30, 2003, pages 1426 - 1435
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NISHIMOTO ET AL., BLOOD, vol. 95, 2000, pages 56 - 61
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KOURO ET AL., INT. IMMUNOL., vol. 21, 2009, pages 1303 - 1309
KULAGOWSKI ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, 2012, pages 5901 - 5921
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See also references of EP 3424930A4
O'SULLIVAN ET AL., MOL. IMMUNOL., vol. 44, 2007, pages 2497 - 2506
QUINTAS-CARDAMA ET AL., NAT. REV. DRUG DISCOV., vol. 10, 2011, pages 127 - 140
HAAN ET AL., CHEM. BIOL., vol. 18, 2011, pages 314 - 323
GAN ET AL., BIODRUGS, vol. 27, 2013, pages 359 - 373
MIHARA ET AL., CLIN. SCI. (LOND., vol. 122, 2012, pages 143 - 159
WALLACE ET AL., 71ST ANN. MEET. AM. COLL. RHEUMATOL., 2007
GLIOZZI ET AL., J. AUTOIMMUN., vol. 40, 2013, pages 122 - 133
NEURATH ET AL., CYTOKINE GROWTH FACTOR REV., vol. 22, 2011, pages 83 - 89
VUITTON ET AL., CURR. DRUG TARGETS, vol. 14, 2013, pages 1385 - 1391
AKDENIZ ET AL., ANN. ACAD. MED. SINGAPORE, vol. 33, 2004, pages 596 - 599
DALAKAS, ANN. N.Y. ACAD. SCI., vol. 1274, 2012, pages 1 - 8
GOTO ET AL., CLIN. IMMUNOL., vol. 126, 2008, pages 260 - 269
NANBA ET AL., THYROID, vol. 19, 2009, pages 495 - 501
STROBER ET AL., BR. J. DERMATOL., vol. 169, 2013, pages 992 - 999
CHRISTNER ET AL., CURR. OPIN. RHEUMATOL., vol. 16, 2004, pages 746 - 752
DONG ET AL., LUPUS, vol. 16, 2007, pages 101 - 109
LIM ET AL., CORNEA, vol. 34, 2015, pages 248 - 252
SAADOUN ET AL., ARTHRITIS RHEUMATOL., vol. 67, 2015, pages 1353 - 1360
KIEFFER ET AL., REV. MED. INTERNE., vol. 35, 2014, pages 56 - 59
TAKENAKA ET AL., CLIN. RHEUMATOL., vol. 33, 2014, pages 287 - 289
KOBOLD ET AL., CLIN. EXP. RHEUMATOL., vol. 17, 1999, pages 433 - 440
VAGLIO ET AL., ALLERGY, vol. 68, 2013, pages 261 - 273
GONO ET AL., RHEUMATOLOGY, vol. 53, 2014, pages 2196 - 2203
ARAKI ET AL., NEUROLOGY, vol. 82, 2014, pages 1302 - 1306
BAO ET AL., JAKSTAT, vol. 2, 2013, pages e24137
TAKANAMI-OHNISHI ET AL., J. BIOL. CHEM., vol. 277, 2002, pages 37896 - 37903
ANTONIU, CURR. OPIN. INVESTIG. DRUGS, vol. 11, 2010, pages 1286 - 1294
SOKOLOWSKA-WOJDYLO ET AL., J. EUR. ACAD. DERMATOL. VENEREOL., vol. 27, 2013, pages 662 - 664
BROWN ET AL., EUR. FOOD RES. TECHNOL., vol. 235, 2012, pages 971 - 980
LEGRAND ET AL., J. ALLERGY CLIN. IMMUNOL. PRACT., vol. 3, 2015, pages 167 - 174
KITA ET AL., AM. J. RESPIR. CRIT. CARE MED., vol. 153, 1996, pages 1437 - 1441
SOUTHWORTH ET AL., BR. J. PHARMACOL., vol. 166, 2012, pages 2070 - 2083
VAN ZELE ET AL., ALLERGY, vol. 61, 2006, pages 1280 - 1289
NABAVI ET AL., ALLERGOL. IMMUNOPATHOL. (MADR., vol. 42, 2014, pages 465 - 471
SAKAI ET AL., CURR. EYE RES., vol. 38, 2013, pages 825 - 834
BEEKHUIZEN ET AL., EUR. CELL MATER., vol. 26, 2013, pages 80 - 90
ABE, NIHON RINSHO, vol. 72, 2014, pages 1548 - 1553
SLAVOV ET AL., CLIN. EXP. RHEUMATOL., vol. 23, 2005, pages 219 - 226
KAWAKAMI ET AL., ACTA. DERM. VENEREOL., vol. 92, 2012, pages 322 - 323
GULHAN ET AL., PEDIATR. NEPHROL., vol. 30, 2015, pages 1269 - 1277
COSTA-PEREIRA ET AL., AM. J. CANCER RES., vol. 1, 2011, pages 806 - 816
VAINCHENKER ET AL., SEMIN. CELL DEV. BIOL., vol. 19, 2008, pages 385 - 393
LI ET AL., NEOPLASIA, vol. 12, 2010, pages 28 - 38
MASUDA ET AL., OTOL. NEUROTOL., vol. 33, 2012, pages 1142 - 1150
DONATE-CORREA ET AL., J. DIABETES RES., 2015, pages 948417
ZHANG ET AL., ARCH. DERMATOL. RES., vol. 307, 2015, pages 319 - 331
NISHIMOTO ET AL., J. RHEUMATOL., vol. 30, 2003, pages 1426 - 1435
YOKOTA ET AL., LANCET, vol. 371, 2008, pages 998 - 1006
NISHIMOTO ET AL., BLOOD, vol. 95, 2000, pages 56 - 61
NASHAN ET AL., LANCET, vol. 350, 1997, pages 1193 - 1198
KOURO ET AL., INT. IMMUNOL., vol. 21, 2009, pages 1303 - 1309
KULAGOWSKI ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, 2012, pages 5901 - 5921
MALERICH ET AL., BIOORG. MED. CHEM. LETT., vol. 20, 2010, pages 7454 - 7457
ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 13, 2009, pages 263 - 267
JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, 2010, pages 6386 - 6397
See also references of EP 3424930A4
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