CRYSTAL COMPRISING (2R)-2-PROPYLOCTOIC ACID AND AMINE

Title:

CRYSTAL COMPRISING (2R)-2-PROPYLOCTOIC ACID AND AMINE

Document Type and Number:

WIPO Patent Application WO/2005/105722

Kind Code:

A1

Abstract:

Crystals comprising (2R)-2-propyloctoic acid and an amine which retain the pharmacological effect of (2R)-2-propyloctoic acid and can be safely used as a medicinal raw drug for peroral solid preparations. Of these crystals, the crystals especially with dibenzylamine are advantageous because not only the crystals themselves are useful as a medicinal raw drug but also use of the crystals as an intermediate can yield (2R)-2-propyloctoic acid having an optical purity exceeding 99.5%e.e., which has not been obtained hitherto.

Inventors:

HASEGAWA TOMOYUKI (JP)
KAWANAKA YASUFUMI (JP)
KASAMATSU EIJI (JP)

Application Number:

PCT/JP2005/008462

Publication Date:

November 10, 2005

Filing Date:

April 27, 2005

Export Citation:

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Assignee:

ONO PHARMACEUTICAL CO (JP)
HASEGAWA TOMOYUKI (JP)
KAWANAKA YASUFUMI (JP)
KASAMATSU EIJI (JP)

International Classes:

A61K31/20; A61K45/00; A61P9/10; A61P25/00; A61P25/16; A61P25/28; A61P31/04; A61P31/18; A61P35/00; A61P43/00; C07C51/41; C07C51/43; C07C53/128; (IPC1-7): C07C53/128; A61K31/20; A61K45/00; A61P9/10; A61P25/00; A61P25/16; A61P25/28; A61P31/04; A61P31/18; A61P35/00; A61P43/00; C07C51/41; C07C51/43

Domestic Patent References:

WO2003051852A1	2003-06-26
WO2000048982A1	2000-08-24
WO2003051852A1	2003-06-26

Foreign References:

JPH08291106A	1996-11-05
EP0632008A1	1995-01-04
EP1174131A1	2002-01-23

Other References: