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Title:
CRYSTAL OF CYTIDINE DIPHOSPHATE CHOLINE AND PRODUCTION PROCESS THEFEFOR
Document Type and Number:
WIPO Patent Application WO/2018/066690
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: crystals of cytidine diphosphate choline which contain no methanol and have improved powder properties; and a process for producing the crystals. The process according to the present invention comprises precipitating crystals of cytidine diphosphate choline in an aqueous solution containing cytidine diphosphate choline dissolved therein, collecting the precipitated crystals of cytidine diphosphate choline, and washing the collected crystals of cytidine diphosphate choline with an aqueous solution of an organic solvent other than methanol, the aqueous solution having a water content of 5-50 vol%. Thus, crystals of cytidine diphosphate choline which contain no methanol and have improved powder properties can be obtained.

Inventors:
FUKUMOTO KAZUNARI (JP)
Application Number:
JP2017/036463
Publication Date:
April 12, 2018
Filing Date:
October 06, 2017
Export Citation:
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Assignee:
KYOWA HAKKO BIO CO LTD (JP)
International Classes:
C07H19/10
Domestic Patent References:
WO2007018259A12007-02-15
WO2008047792A12008-04-24
Foreign References:
JPS4637749B1
US3687932A1972-08-29
CN101538300A2009-09-23
JPS5132630B11976-09-14
JPS51108076A1976-09-25
JP6166786B22017-07-19
JPS5132630B11976-09-14
JPS647367A1989-01-11
JP3369236B22003-01-20
JP4977608B22012-07-18
JP2016197695A2016-11-24
Other References:
YAMAGISHI, TAKAMICHI: "Passage, A Laboratory Guide to Organic Chemical Experiment for Young Chemists", A LABORATORY GUIDE TO ORGANIC CHEMICAL EXPERIMENT FOR YOUNG CHEMISTS, 10 March 2010 (2010-03-10), pages 132 - 133, XP009515254, ISBN: 978-4-06-154375-1
CYTIDINE 5' -DIPHOSPHATE CHOLINE MONOHYDRATE, vol. 34, no. 3, 1975, pages 358 - 368, XP9515009
See also references of EP 3524613A4
Attorney, Agent or Firm:
EIKOH PATENT FIRM, P.C. (JP)
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