Title:
CRYSTAL FORM OF PPARα AGONIST, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/034114
Kind Code:
A1
Abstract:
Provided are crystal form I and crystal form II of (R)-2-[3-[[N-(benzoxazole-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl)phenoxy]butyric acid. The above-mentioned two crystal forms have a good illumination stability, a good high-temperature stability and a good high-humidity stability.
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Inventors:
RUAN SHIGANG (CN)
HUANG JIAJUN (CN)
HUANG JIAJUN (CN)
Application Number:
PCT/CN2018/100566
Publication Date:
February 20, 2020
Filing Date:
August 15, 2018
Export Citation:
Assignee:
SHENZHEN JINGTAI TECH CO LTD (CN)
International Classes:
C07D263/58; A61K31/423; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P29/00
Foreign References:
| EP1852426A1 | 2007-11-07 | |||
| EP1854779A1 | 2007-11-14 |
Other References:
YAMAZAKI, YUKIYOSHI: "A practical synthesis of the PPARalfa agonist, (R)- K-13675, starting from (S)-2-hydroxybutyrolactone", TETRAHEDRON, vol. 64, no. 35, 19 June 2008 (2008-06-19), pages 8155 - 8158, XP022931249
Attorney, Agent or Firm:
SUNSHINE INTELLECTUAL PROPERTY INTERNATIONAL CO., LTD (CN)
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