Title:
CRYSTAL FORM OF AZACYCLOBUTYL NICOTINIC ACID COMPOUND AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/125904
Kind Code:
A1
Abstract:
The present invention relates to a crystal form of an azacyclobutyl nicotinic acid compound and a preparation method therefor. The present invention provides crystal forms B, D, E and K of a compound of formula (I) as well as preparation methods therefor and applications thereof. The crystal forms B, D, E and K of the compound of formula (I) provided by the present invention have advantages in at least one of the following aspects such as solubility, melting point, stability, dissolution rate, hygroscopicity, adhesiveness, fluidity, bioavailability, processability, purification, preparation production, and safety, provide a new and better option for the preparation of a pharmaceutical preparation comprising the compound of formula (I), and are of great significance for pharmaceutical development.
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Inventors:
LU XIA (CN)
CHEN ZHIXIONG (CN)
ZHANG XIAOYU (CN)
CHEN ZHIXIONG (CN)
ZHANG XIAOYU (CN)
Application Number:
PCT/CN2022/143827
Publication Date:
July 06, 2023
Filing Date:
December 30, 2022
Export Citation:
Assignee:
CRYSTAL PHARMATECH CO LTD (CN)
International Classes:
C07D413/14; A61K31/4427; A61P1/16; A61P3/10
Domestic Patent References:
| WO2018169742A1 | 2018-09-20 |
Foreign References:
| CN103702719A | 2014-04-02 | |||
| CN113439078A | 2021-09-24 | |||
| CN113573700A | 2021-10-29 |
Other References:
XIANG CEN ，, GAO FENG, KONG XIANGSHUN, LIU JIANG, LI MINGYUAN, YUAN YUAN, TENG YUOU: "Research Progress of Farnesoid X Receptor Agonists ", HERALD OF MEDICINE, HUAZHONG KEJI DAXUE TONGJI YIXUEYUAN FUSHU TONGJI YIYUAN, CN, vol. 40, no. 5, 29 April 2021 (2021-04-29), CN , pages 645 - 650, XP093075978, ISSN: 1004-0781
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