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Title:
CRYSTAL FORM OF DAPAGLIFLOZIN INTERMEDIATE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2018/014866
Kind Code:
A1
Abstract:
Disclosed are a crystal form of a dapagliflozin intermediate and a preparation method therefor, and specifically disclosed are a crystal form of the dapagliflozin intermediate (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-2-ethoxy-6-(methylhydroxyl)tetrahydro-2H-pyran-3,4,5-triol and a preparation method therefor. The advantages thereof lie in that an intermediate can be highly purified to obtain a sample with a purity of 99.3% or more, wherein same has an important significance for improving the quality of the dapagliflozin, and the preparation process is simple and suitable for industrial production.

Inventors:
LI XIANG (CN)
YU JUN (CN)
YU HAIZHOU (CN)
WANG JINJIA (CN)
HE LEI (CN)
DU ZUYIN (CN)
Application Number:
PCT/CN2017/093833
Publication Date:
January 25, 2018
Filing Date:
July 21, 2017
Export Citation:
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Assignee:
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
International Classes:
C07H15/04; A61P3/10; C07D309/10; C07H1/00
Domestic Patent References:
WO2015132803A22015-09-11
WO2013152654A12013-10-17
Foreign References:
CN105481915A2016-04-13
CN104109179A2014-10-22
Other References:
See also references of EP 3489250A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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