Title:
CRYSTAL FORM OF DAPAGLIFLOZIN INTERMEDIATE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2018/014866
Kind Code:
A1
Abstract:
Disclosed are a crystal form of a dapagliflozin intermediate and a preparation method therefor, and specifically disclosed are a crystal form of the dapagliflozin intermediate (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-2-ethoxy-6-(methylhydroxyl)tetrahydro-2H-pyran-3,4,5-triol and a preparation method therefor. The advantages thereof lie in that an intermediate can be highly purified to obtain a sample with a purity of 99.3% or more, wherein same has an important significance for improving the quality of the dapagliflozin, and the preparation process is simple and suitable for industrial production.
Inventors:
LI XIANG (CN)
YU JUN (CN)
YU HAIZHOU (CN)
WANG JINJIA (CN)
HE LEI (CN)
DU ZUYIN (CN)
YU JUN (CN)
YU HAIZHOU (CN)
WANG JINJIA (CN)
HE LEI (CN)
DU ZUYIN (CN)
Application Number:
PCT/CN2017/093833
Publication Date:
January 25, 2018
Filing Date:
July 21, 2017
Export Citation:
Assignee:
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
International Classes:
C07H15/04; A61P3/10; C07D309/10; C07H1/00
Domestic Patent References:
WO2015132803A2 | 2015-09-11 | |||
WO2013152654A1 | 2013-10-17 |
Foreign References:
CN105481915A | 2016-04-13 | |||
CN104109179A | 2014-10-22 |
Other References:
See also references of EP 3489250A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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