Title:
CRYSTAL FORM II OF ELOBIXIBAT AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/027013
Kind Code:
A1
Abstract:
A crystal form II of elobixibat. The X-ray powder diffraction pattern of the crystal form II has specific peaks at 2θ values 9.4±0.2° and 7.8±0.2° and has one or more of following characteristic peaks: 3.9±0.2°, 11.7±0.2°, 16.1±0.2°, 17.6±0.2°, 18.3±0.2°, 19.6±0.2°, 20.9±0.2°, 22.1±0.2°, and 25.8±0.2°. The crystal form II is stable and has low hygroscopicity; when exposed to a high-humidity environment of 25°C/92.5%RH, the chemical purity of the crystal form II does not change significantly, and the X-ray powder diffraction pattern of the crystal form likewise does not change; moreover, the crystal form II involves a simple and convenient preparation method, has low requirements with respect to the preparation process and storage conditions, and has high medicinal value.
Inventors:
CAO MING (CN)
CHEN YUFENG (CN)
CHEN DAOYU (CN)
ZOU JIE (CN)
ZHANG ZIWEI (CN)
JIN FEIMIN (CN)
YANG SHAOBO (CN)
ZHENG BAOFU (CN)
GAO QIANG (CN)
CHEN YUFENG (CN)
CHEN DAOYU (CN)
ZOU JIE (CN)
ZHANG ZIWEI (CN)
JIN FEIMIN (CN)
YANG SHAOBO (CN)
ZHENG BAOFU (CN)
GAO QIANG (CN)
Application Number:
PCT/CN2022/124083
Publication Date:
February 08, 2024
Filing Date:
October 09, 2022
Export Citation:
Assignee:
SHANGHAI HAOYUAN CHEMEXPRESS CO LTD (CN)
International Classes:
C07D281/10; A61K31/554; A61P3/00; A61P3/06
Foreign References:
| EP4029860A1 | 2022-07-20 | |||
| CN107001301A | 2017-08-01 | |||
| CN111836804A | 2020-10-27 | |||
| CN1481373A | 2004-03-10 | |||
| CN105143194A | 2015-12-09 |
Attorney, Agent or Firm:
SHANGCHENG & PARTNERS (CN)
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