Title:
CRYSTAL FORM OF LANIFIBRANOR, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/122014
Kind Code:
A1
Abstract:
Provided are a new crystal form of Lanifibranor (referred to as "compound I") and a preparation method therefor, a pharmaceutical composition containing the crystal form, and a use of the crystal form in preparation of a pan-PPAR agonist drug and a drug for treating non-alcoholic steatohepatitis. Compared with the prior art, the provided new crystal form of the compound I has one or more improved properties, solves the problems existing in the prior art, and is of great value to the optimization and development of the drug containing the compound I.
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Inventors:
CHEN MINHUA (CN)
ZHU HONGYAN (CN)
ZHU HONGYAN (CN)
Application Number:
PCT/CN2021/137078
Publication Date:
June 16, 2022
Filing Date:
December 10, 2021
Export Citation:
Assignee:
CRYSTAL PHARMACEUTICAL SUZHOU CO LTD (CN)
International Classes:
C07D417/12; A61K31/404; A61K31/428; A61P1/16; A61P29/00; C07D209/12
Foreign References:
| IN201911052572A | 2021-09-03 | |||
| CN109316601A | 2019-02-12 | |||
| CN101248044A | 2008-08-20 |
Other References:
BENAïSSA BOUBIA , OLIVIA POUPARDIN, MARTINE BARTH, JEAN BINET, PHILIPPE PERALBA, LAURENT MOUNIER, ELISE JACQUIER, EMILIE GAUT: "Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) alpha/gamma/delta Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate", JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, no. 6, 22 March 2018 (2018-03-22), pages 2246 - 2265, XP002790345, DOI: 10.1021/acs.jmedchem.7b01285
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