Title:
CRYSTAL FORM OF OREXIN RECEPTOR ANTAGONIST, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/024845
Kind Code:
A1
Abstract:
A crystal form of a compound Lemborexant, a preparation method therefor, a pharmaceutical composition comprising the crystal form, and use of the crystal form in the preparation of an orexin receptor antagonist and of a pharmaceutical formulation for treating insomnia and irregular sleep-wake rhythm disorder. The crystal form of the compound Lemborexant provided by the present invention has one or more improved properties with respect to the prior art, having great value for the optimization and development of this medicament in the future.
Inventors:
CHEN MINHUA (CN)
ZHANG YANFENG (CN)
HUANG CHUNXIANG (CN)
ZHANG XIAOYU (CN)
ZHANG YANFENG (CN)
HUANG CHUNXIANG (CN)
ZHANG XIAOYU (CN)
Application Number:
PCT/CN2018/097797
Publication Date:
February 07, 2019
Filing Date:
July 31, 2018
Export Citation:
Assignee:
CRYSTAL PHARMACEUTICAL SUZHOU CO LTD (CN)
International Classes:
A61K31/506; C07D239/34; A61P25/20
Domestic Patent References:
| WO2016063995A1 | 2016-04-28 |
Foreign References:
| CN104114524A | 2014-10-22 | |||
| CN104592184A | 2015-05-06 | |||
| CN103153963A | 2013-06-12 |
Download PDF: