Title:
CRYSTAL FORM OF OXAZINANE COMPOUND AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2015/087853
Kind Code:
A1
Abstract:
Provided are: a crystal form of (-)-(2-{[3-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]methyl}-1,3-oxazinan-3-yl)[5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone, said crystal form being stable in the environment of usage thereof as a medicine; and a method for preparing the same. The present invention is crystals of (-)-(2-{[3-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]methyl}-1,3-oxazinan-3-yl)[5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone which have at least one of characteristics (a) to (c): (a) in powder X-ray diffraction (Cu-Kα), peaks appear at 2θ=11.1º, 12.5º, 20.3º and 24.2º; (b) the melting point is 124 to 129 ºC; and (c) in the infrared absorption spectrum, characteristic absorption bands appear at 1627cm-1, 1504 cm-1, 1226 cm-1, 1076 cm-1, 822 cm-1 and 783 cm-1. The present invention is also a method for preparing the crystals which is characterized by comprising: dissolving (-)-(2-{[3- (5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]methyl}-1,3-oxazinan-3-yl)[5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone in a mixed solvent consisting of water and either a lower alcohol or acetone; and subjecting the solution to crystallization and then drying.
Inventors:
FUTAMURA AYA (JP)
HATTORI NOBUTAKA (JP)
URABE HIROKI (JP)
OGATA YUYA (JP)
OSAKI NAOTO (JP)
HATTORI NOBUTAKA (JP)
URABE HIROKI (JP)
OGATA YUYA (JP)
OSAKI NAOTO (JP)
Application Number:
PCT/JP2014/082497
Publication Date:
June 18, 2015
Filing Date:
December 09, 2014
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
International Classes:
C07D413/14; A61K31/5355; A61P1/00; A61P1/14; A61P5/00; A61P9/12; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P29/00; A61P37/00; A61P43/00
Domestic Patent References:
| WO2013187467A1 | 2013-12-19 | |||
| WO2013068935A1 | 2013-05-16 |
Foreign References:
| JP2005501026A | 2005-01-13 | |||
| JP2004533440A | 2004-11-04 | |||
| JP2004534026A | 2004-11-11 | |||
| JP2012506376A | 2012-03-15 |
Attorney, Agent or Firm:
ASAMURA PATENT OFFICE, p. c. (JP)
Patent business corporation Asamura patent firm (JP)
Patent business corporation Asamura patent firm (JP)
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