Title:
CRYSTAL FORM A OF PRAMIPEXOLE XINAFOATE SALT AND PREPARATION METHOD FOR CRYSTAL FORM A
Document Type and Number:
WIPO Patent Application WO/2024/021625
Kind Code:
A1
Abstract:
A crystal form A of pramipexole xinafoate salt ((S)-(-)-2-amino-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazole bis(1-hydroxynaphthoate) and a preparation method for the crystal form A. The structural formula of the pramipexole xinafoate salt is as follows: (I). The X-ray powder diffraction pattern of the crystal form A of the pramipexole xinafoate salt has diffraction peaks at 2θ(°) values of 7.80±0.20°, 10.64±0.20°, 10.76±0.20°, 13.95±0.20°, 19.15±0.20°, 22.67±0.20°, 24.64±0.20°, 25.49±0.20°, 26.39±0.20°, and 27.26±0.20°. A suspension injection prepared from the crystal form A has an obvious sustained release effect.
Inventors:
SUN YINGJI (CN)
XING XIAOYAN (CN)
WANG YUGUANG (CN)
LI TIEJUN (CN)
LIU SHANKUI (CN)
XING XIAOYAN (CN)
WANG YUGUANG (CN)
LI TIEJUN (CN)
LIU SHANKUI (CN)
Application Number:
PCT/CN2023/081207
Publication Date:
February 01, 2024
Filing Date:
March 14, 2023
Export Citation:
Assignee:
JEWIM PHARMACEUTICAL SHANDONG CO LTD (CN)
International Classes:
C07D277/82; A61K31/428; A61P25/16; C07C51/43; C07C65/11; C07D277/60
Domestic Patent References:
| WO2007054970A2 | 2007-05-18 |
Foreign References:
| CN115141161A | 2022-10-04 | |||
| CN111212640A | 2020-05-29 | |||
| CN107540632A | 2018-01-05 | |||
| US20070059717A1 | 2007-03-15 |
Other References:
XIURONG HU, SHEN JIN, SUXIANG WU, JIAJIA WU: "Preparation and Characterization of Form B of Pramipexole Dihydrochloride", CHINESE JOURNAL OF MODERN APPLIED PHARMACY, vol. 32, no. 9, 22 September 2015 (2015-09-22), pages 1086 - 1090, XP093132644, DOI: 10.13748/j.cnki.issn1007-7693.2015.09.014
ELSNER, JAN ET AL.: "Pharmacophore-Guided Drug Discovery Investigations Leading to Bioactive 5-Aminotetrahydropyrazolopyridines. Implications for the Binding Mode of Heterocyclic Dopamine D3 Receptor Agonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, no. 18, 11 August 2005 (2005-08-11), pages 5771 - 5779, XP002520691, DOI: 10.1021/JM0503805
ELSNER, JAN ET AL.: "Pharmacophore-Guided Drug Discovery Investigations Leading to Bioactive 5-Aminotetrahydropyrazolopyridines. Implications for the Binding Mode of Heterocyclic Dopamine D3 Receptor Agonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, no. 18, 11 August 2005 (2005-08-11), pages 5771 - 5779, XP002520691, DOI: 10.1021/JM0503805
Attorney, Agent or Firm:
NANJING IPLEADER INTELLECTUAL PROPERTY AGENCY FIRM (CN)
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