Title:
CRYSTAL FORM AND PREPARATION METHOD OF 5-[2,6-DI(4-MORPHOLINYL)-4-PYRIMIDINYL]-4-(TRIFLUOROMETHYL)-2-PYRIDINAMINE HYDROCHLORIDE
Document Type and Number:
WIPO Patent Application WO/2017/050111
Kind Code:
A1
Abstract:
The invention relates to a crystal form H and a preparation method of a 5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine monohydrochloride. An x-ray powder diffraction pattern of the crystal form H in 25°C comprises characteristic peaks of a 2theta value at 16.6°±0.2°, 15.8°±0.2°, and 18.5°±0.2°. In comparison to a conventional crystal form, the crystal form H has favorable stability and low hygroscopicity, and is significant in drug development.
Inventors:
CHEN MINHUA (CN)
ZHANG YANFENG (CN)
DIAO XIAOJUAN (CN)
ZHANG XIAOYU (CN)
ZHANG YANFENG (CN)
DIAO XIAOJUAN (CN)
ZHANG XIAOYU (CN)
Application Number:
PCT/CN2016/097774
Publication Date:
March 30, 2017
Filing Date:
September 01, 2016
Export Citation:
Assignee:
CRYSTAL PHARMATECH CO LTD (CN)
International Classes:
C07D401/14; C07D239/28; C07D239/42; C07D401/04
Domestic Patent References:
| WO2012044727A2 | 2012-04-05 | |||
| WO2014064058A1 | 2014-05-01 |
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT & TREADMARK AGENCY LTD. (CN)
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