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Title:
CRYSTAL FORM OF PURINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/274310
Kind Code:
A1
Abstract:
A crystal form of substituted purine derivatives and pharmaceutical compositions thereof, preparation methods, and uses for preparing a DNA-PK inhibitor are related to. Specifically, a crystal form of a compound represented by formula (A), pharmaceutical compositions thereof, preparation methods, and uses for preparing a DNA-PK inhibitor are related to.

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Inventors:
XU XUEZHEN (CN)
LEI FEIQUAN (CN)
ZHU DAN (CN)
HE LVXUE (CN)
WEI YONGGANG (CN)
SUN YI (CN)
Application Number:
PCT/CN2022/102452
Publication Date:
January 05, 2023
Filing Date:
June 29, 2022
Export Citation:
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Assignee:
CHENGDU BAIYU PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D519/00; A61K31/522; A61P35/00; C07D473/32
Domestic Patent References:
WO2021136463A12021-07-08
WO2021104277A12021-06-03
WO2019238929A12019-12-19
WO2018114999A12018-06-28
Foreign References:
CN114573605A2022-06-03
Other References:
GOLDBERG FREDERICK W., FINLAY M. RAYMOND V., TING ATTILLA K. T., BEATTIE DAVID, LAMONT GILLIAN M., FALLAN CHARLENE, WRIGLEY GAIL L: "The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5- a ]pyridin-6-yl)amino]-9-(tetrahydro-2 H -pyran-4-yl)-7,9-dihydro-8 H -purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 63, no. 7, 9 April 2020 (2020-04-09), US , pages 3461 - 3471, XP055826430, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b01684
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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