Title:
CRYSTAL FORM OF PYRIMIDINE DERIVATIVE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/268063
Kind Code:
A1
Abstract:
The present invention relates to the field of chemical pharmacy, relates to a crystal form of a pyrimidine derivative and a preparation method therefor, and specifically relates to crystal forms A, B, C, D, and E of a compound of formula (I), a preparation method therefor, and a pharmaceutical composition and use thereof. The present invention solves the problems of small granularity, poor fluidity, poor stability and the like of the compound of formula (I) present in an amorphous form. The crystal form prepared by the present invention and the pharmaceutical composition thereof can be used for preparing a drug for treating a cancer disease.
Inventors:
ZHAO MEIYU (CN)
CHEN LIANWEI (CN)
LI NA (CN)
SHI ZHENJUAN (CN)
ZHENG JIANFENG (CN)
SU DI (CN)
CHEN LIANWEI (CN)
LI NA (CN)
SHI ZHENJUAN (CN)
ZHENG JIANFENG (CN)
SU DI (CN)
Application Number:
PCT/CN2022/100065
Publication Date:
December 29, 2022
Filing Date:
June 21, 2022
Export Citation:
Assignee:
ZHE JIANG HISUN PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D403/12; A61K31/506; A61P35/00; C07D471/10; C07D487/10
Domestic Patent References:
| WO2017198221A1 | 2017-11-23 | |||
| WO2015059668A1 | 2015-04-30 | |||
| WO2015057938A1 | 2015-04-23 | |||
| WO2015057963A1 | 2015-04-23 | |||
| WO2017198221A1 | 2017-11-23 |
Foreign References:
| CN109422760A | 2019-03-05 |
Other References:
FRENCH ET AL., PLOS ONE, vol. 7, no. 5, 2012, pages e367313
SIA ET AL., GASTROJTEROLOGY, vol. 144, 2013, pages 829 - 840
BROWN, AP ET AL., TOXOCOL. PATHOL., 2005, pages 449 - 455
SIA ET AL., GASTROJTEROLOGY, vol. 144, 2013, pages 829 - 840
BROWN, AP ET AL., TOXOCOL. PATHOL., 2005, pages 449 - 455
Download PDF:
Previous Patent: TESTCASE SELECTION METHOD AND RELATED APPARATUS
Next Patent: DATA TRANSMISSION METHOD AND RELATED APPARATUS
Next Patent: DATA TRANSMISSION METHOD AND RELATED APPARATUS