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Title:
CRYSTAL FORM OF R228060 HYDROCHLORIDE AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/133703
Kind Code:
A1
Abstract:
The present invention relates to crystal forms of R228060 hydrochloride and a preparation method and use thereof. The crystal forms CS1 and CS2 of R228060 hydrochloride provided by the present invention have good stabilities, high solubilities, high melting points, good crystallinities, and low hygroscopicities, the preparation method thereof is simple, and are suitable for drug development. The discovery of crystal forms CS1 and CS2 of R228060 hydrochloride provides a better choice for the preparation of a pharmaceutical preparation comprising the R228060 hydrochloride and is of great significance for drug development.

Inventors:
CHEN, Minhua (ZHAO, LinlinB4-301, Biobay, 218 Xinghu Street,Suzhou Industrial Par, Suzhou Jiangsu 3, 215123, CN)
ZHANG, Yanfeng (ZHAO, LinlinB4-301, Biobay, 218 Xinghu Street,Suzhou Industrial Par, Suzhou Jiangsu 3, 215123, CN)
DIAO, Xiaojuan (ZHAO, LinlinB4-301, Biobay, 218 Xinghu Street,Suzhou Industrial Par, Suzhou Jiangsu 3, 215123, CN)
HUANG, Chunxiang (ZHAO, LinlinB4-301, Biobay, 218 Xinghu Street,Suzhou Industrial Par, Suzhou Jiangsu 3, 215123, CN)
ZHANG, Xiaoyu (ZHAO, LinlinB4-301, Biobay, 218 Xinghu Street,Suzhou Industrial Par, Suzhou Jiangsu 3, 215123, CN)
Application Number:
CN2018/071889
Publication Date:
July 26, 2018
Filing Date:
January 09, 2018
Export Citation:
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Assignee:
CRYSTAL PHARMACEUTICAL (SUZHOU) CO., LTD. (ZHAO, LinlinB4-301, Biobay, 218 Xinghu Street,Suzhou Industrial Par, Suzhou Jiangsu 3, 215123, CN)
International Classes:
C07C269/00; C07C271/12; A61K31/132; A61K31/137; A61K31/223
Foreign References:
CN1135209A1996-11-06
CN1867542A2006-11-22
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