Title:
CRYSTAL FORM OF RENAL OUTER MEDULLARY POTASSIUM CHANNEL INHIBITOR AND PREPARATION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/109935
Kind Code:
A1
Abstract:
The present invention provides a crystal form of a renal outer medullary potassium channel inhibitor and a preparation method thereof. In particular, the present invention provides crystal form III of a L-tartrate of a renal outer medullary potassium channel (ROMK) inhibitor (I) and a preparation method thereof. The crystal form III has good chemical stability and crystal form stability, and the crystallization solvent used has low toxicity and residue. Thus, the present invention can be better used in clinical treatment.
Inventors:
WU GUAILI (CN)
ZHANG QUANLIANG (CN)
LU YUN (CN)
YAO FEI (CN)
ZHANG QUANLIANG (CN)
LU YUN (CN)
YAO FEI (CN)
Application Number:
PCT/CN2018/119310
Publication Date:
June 13, 2019
Filing Date:
December 05, 2018
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
International Classes:
C07D405/14; A61K31/4545; A61P9/04; A61P9/12
Domestic Patent References:
| WO2016091042A1 | 2016-06-16 | |||
| WO2014085210A1 | 2014-06-05 | |||
| WO2017211271A1 | 2017-12-14 | |||
| WO2016091042A1 | 2016-06-16 |
Foreign References:
| CN104540826A | 2015-04-22 | |||
| CN102459216A | 2012-05-16 | |||
| CN201711273099A | 2017-12-06 |
Other References:
See also references of EP 3722293A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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