Title:
CRYSTAL FORM OF SALVIANOLIC ACID A, AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2018/137502
Kind Code:
A1
Abstract:
The present invention relates to the field of pharmaceutical chemistry, and in particular, to a crystal form of salvianolic acid A, and a method for preparing same. The X-ray powder diffraction pattern of a crystal form I shows characteristic peaks at 2θ values of 7.08 ± 0.2°, 11.94±0.2°, 14.23±0.2°, 16.41±0.2°, 17.99±0.2°, 21.41±0.2°, 21.83±0.2°, 22.47±0.2°, and 25.76±0.2°. The crystal form I of salvianolic acid A provided by the present invention has good stability, is not easy to be oxidized or deliquated under the influence of high temperature and high humidity, facilitates long-term storage of drugs, and can better avoid crystal transformation during drug research and development. Moreover, the purity of the crystal form I prepared in the present invention is higher than 99%, and is suitable as an active pharmaceutical ingredient (API) for research and development of pharmaceutical preparations.
Inventors:
YE TIANJIAN (CN)
KAN SHIDONG (CN)
ZHANG ZHIJIE (CN)
LU XIUWEI (CN)
HE YUANKANG (CN)
CAO HUANYING (CN)
CHEN GUILAN (CN)
KAN SHIDONG (CN)
ZHANG ZHIJIE (CN)
LU XIUWEI (CN)
HE YUANKANG (CN)
CAO HUANYING (CN)
CHEN GUILAN (CN)
Application Number:
PCT/CN2018/072432
Publication Date:
August 02, 2018
Filing Date:
January 12, 2018
Export Citation:
Assignee:
ZHEJIANG YONGNING PHARMACEUTICAL CO LTD (CN)
International Classes:
C07C67/52; C07C69/732
Foreign References:
| CN101712618A | 2010-05-26 | |||
| CN105523926A | 2016-04-27 | |||
| CN105481809A | 2016-04-13 |
Attorney, Agent or Firm:
HANGZHOU ZHONGCHENG PATENT AGENCY CO., LTD. (CN)
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