Title:
CRYSTAL FORM SODIUM SALT OF REBAUDIOSIDE B AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/143956
Kind Code:
A1
Abstract:
The present invention relates to a naturally-extracted high potency sweetener rebaudioside, and particularly relates to a novel crystal form of a sodium salt of rebaudioside B and a preparation method thereof. The novel crystal form is comprehensively characterized using means of solid chemical analysis such as XRD, DSC, TGA, DVS, and the like, with the finding that the novel crystal form has the characteristics of a high crystallinity, stable physico-chemical properties, good water solubility, low hygroscopicity, and high flowability. The novel crystal form therefore has superior physico-chemical properties and is suitable for a wider range of applications. A preparation method of a novel crystal form A of the sodium salt of rebaudioside B is simple, easily controlled, and reproducible to provide a steady supply of the target crystal form.
Inventors:
ZHU LIPING (CN)
MEI XUEFENG (CN)
HUANG YING (CN)
WANG JIANRONG (CN)
MEI XUEFENG (CN)
HUANG YING (CN)
WANG JIANRONG (CN)
Application Number:
PCT/CN2017/074114
Publication Date:
August 31, 2017
Filing Date:
February 20, 2017
Export Citation:
Assignee:
ZHUCHENG HAOTIAN PHARM CO LTD (CN)
International Classes:
C07H15/256; A23L2/60; A23L27/30; A61K47/26; C07H1/00
Foreign References:
| CN105669794A | 2016-06-15 | |||
| CN103492403A | 2014-01-01 | |||
| US4449997A | 1984-05-22 |
Other References:
DUBOIS, GRANT E. ET AL.: "Diterpenoid Sweeteners. Synthesis and Sensory Evaluation of Stevioside Analogues with Improved Organoleptic Properties", J. MED. CHEM., vol. 28, no. 1, 31 December 1985 (1985-12-31), pages 93 - 98, XP002543470
Attorney, Agent or Firm:
XU & PARTNERS,LLC. (CN)
Download PDF:
Previous Patent: METHOD AND APPARATUS FOR CONTROLLING POWER OF ELECTRIC FURNACE
Next Patent: DATA REDISTRIBUTION METHOD AND DEVICE
Next Patent: DATA REDISTRIBUTION METHOD AND DEVICE