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Title:
CRYSTAL FORMS OF ANTIDEPRESSANT DRUG SAGE-217 AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/147852
Kind Code:
A1
Abstract:
The present application relates to crystal form 04, crystal form 06, crystal form D-1, and crystal form D-2 of an antidepressant drug SAGE-217 and a preparation method therefor and a pharmaceutical composition containing same. The XRPD of crystal form 04 has characteristic peaks at 2theta values of 11.6±0.2°, 13.5±0.2°, 16.2±0.2°, 16.5±0.2°, and 23.2±0.2°; the XRPD of crystal form 06 has characteristic peaks at 2theta values of 8.7±0.2°, 10.0±0.2°, 13.2±0.2°, 15.0±0.2°, 15.8±0.2°, and 17.3±0.2°; the XRPD of crystal form D-1 has characteristic peaks at 2theta values of 7.2±0.2°, 8.6±0.2°, 13.3±0.2°, 19.6±0.2°, and 23.0±0.2°; and the XRPD of crystal form D-2 has characteristic peaks at 2theta values of 7.3±0.2°, 8.6±0.2°, 13.4±0.2°, 19.7±0.2°, and 23.3±0.2°. The new crystal forms provided by the present application have good stability, and provide more choices for drug development.

Inventors:
WANG PENG (CN)
LI PIXU (CN)
CHEN SIPING (CN)
Application Number:
PCT/CN2020/072924
Publication Date:
July 23, 2020
Filing Date:
January 19, 2020
Export Citation:
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Assignee:
SUZHOU PENGXU PHARMATECH CO LTD (CN)
ZHEJIANG EAZY PHARMCHEM CO LTD (CN)
International Classes:
C07J43/00
Domestic Patent References:
WO2019051264A12019-03-14
WO2018039378A12018-03-01
WO2014169833A92016-03-03
WO2018039378A12018-03-01
WO2014169833A12014-10-23
WO2018039378A12018-03-01
Other References:
"Guidelines for Hygroscopicity", article "Appendix XIX J of Chinese Pharmacopoeia"
See also references of EP 3912985A4
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
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