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Title:
CRYSTAL FORMS OF DEMETHYLENE BERBERINE HYDROCHLORIDE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/153644
Kind Code:
A1
Abstract:
Provided are four crystal forms, A, B, C and D, of demethylene berberine hydrochloride, and a preparation method therefor, and further provided are X‑ray powder diffraction characteristic absorption peaks, infrared absorption peaks and DSC spectra of the four crystal forms. The X‑ray powder diffraction characteristic diffraction peaks of the crystal forms are at about 8.205º, 8.805º, 10.817º, 14.835º, 15.479º, 16.668º, 17.492º, 18.529º, 20.656º, 21.536º, 23.538º, 25.657º, 26.192º, and 28.808º. A preparation method for the four crystal forms of the demethylene berberine hydrochloride is also involved. The preparation method has a simple process, a high yield and a low cost; and has a high product purity and a stable quality.

Inventors:
ZHANG YUBIN (CN)
ZHANG YUQIANG (CN)
ZHANG MIAO (CN)
LI QINGXIA (CN)
Application Number:
PCT/CN2018/095341
Publication Date:
August 15, 2019
Filing Date:
July 12, 2018
Export Citation:
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Assignee:
UNIV CHINA PHARMA (CN)
International Classes:
C07D455/03
Domestic Patent References:
WO2009007457A22009-01-15
Foreign References:
CN103816152A2014-05-28
CN102040604A2011-05-04
CN1827618A2006-09-06
CN101153039A2008-04-02
Other References:
LI, Y. H.: "Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine", BIOORG. MED. CHEM., 30 July 2010 (2010-07-30), XP027218830
RIBAUDO, G.: "Preliminary studies of berberine and its semi-synthetic derivatives as a promising class of multi-target anti-parkinson agents", NATURAL PRODUCT RESEACH, vol. 32, no. 12, 10 July 2017 (2017-07-10), pages 1395 - 1401, XP055629140
HUO, LI ET AL.: "Synthesis of rotundine", CHINESE JOURNAL OF PHARMACEUTICALS, vol. 43, no. 5, 31 December 2012 (2012-12-31), pages 323 - 325, XP055629146
Attorney, Agent or Firm:
JW IP LAW FIRM (CN)
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