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Title:
CRYSTAL OF Β-HYDROXY Β-METHYLBUTYRIC ACID AMINO ACID SALT AND PRODUCTION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2017/222043
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a crystal of HMB amino acid salt, which is easy to handle and is highly soluble; and a production method of said crystal. According to the present invention, a crystal of HMB amino acid salt can be precipitated by dissolving HMB amino acid salt in an amorphous state in a solvent containing an alcohol and by agitating said solvent or leaving said solvent still. In addition, a crystal of HMB amino acid salt can be precipitated by concentrating an HMB amino acid salt aqueous solution having a pH of 2.5-11.0.

Inventors:
YOKOI TOMOYA (JP)
NAGANO HIROSHI (JP)
SHIMIZU TAKAYUKI (JP)
Application Number:
PCT/JP2017/023174
Publication Date:
December 28, 2017
Filing Date:
June 23, 2017
Export Citation:
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Assignee:
KYOWA HAKKO BIO CO LTD (JP)
OTSUKA PHARMA FACTORY INC (JP)
International Classes:
C07C59/01; C07C51/41; C07C51/43; C07C229/26
Domestic Patent References:
WO2014166273A12014-10-16
WO2013025775A12013-02-21
Foreign References:
CN1434025A2003-08-06
US20040176449A12004-09-09
JPS58201746A1983-11-24
JPS57128653A1982-08-10
US6248922B12001-06-19
US20040176449A12004-09-09
JP2016125280A2016-06-24
Other References:
JOURNAL OF APPLIED PHYSIOLOGY, vol. 81, 1996, pages 2095
NUTRITION & METABOLISM, vol. 5, 2008, pages 1
JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION, vol. 10, no. 6, 2013
BMJ., vol. 346, 2013, pages 228
See also references of EP 3476825A4
Attorney, Agent or Firm:
EIKOH PATENT FIRM, P.C. (JP)
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