Title:
CRYSTAL OF OXIDIZED ALANYLCYSTEINE AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2011/145639
Kind Code:
A1
Abstract:
Disclosed is a crystal of oxidized alanylcysteine. A crystal of oxidized alanylcysteine, particularly a crystal of oxidized alanylcysteine monohydrate is produced by a method comprising a step of crystallizing oxidized alanylcysteine from a mixed solution of an aqueous solution containing oxidized alanylcysteine and a water-miscible organic solvent.
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Inventors:
NISHIMURA TETSUO
KINO MITSUTAKA
KINO MITSUTAKA
Application Number:
PCT/JP2011/061361
Publication Date:
November 24, 2011
Filing Date:
May 18, 2011
Export Citation:
Assignee:
KYOWA HAKKO BIO CO LTD (JP)
NISHIMURA TETSUO
KINO MITSUTAKA
NISHIMURA TETSUO
KINO MITSUTAKA
International Classes:
C07K5/062; C07K1/02; C07K1/14; C07K1/22
Domestic Patent References:
| WO2006104186A1 | 2006-10-05 | |||
| WO2001088175A1 | 2001-11-22 |
Foreign References:
| JPS59172444A | 1984-09-29 |
Other References:
MAKOTO YAGASAKI ET AL.: "Development of Efficient Dipeptide Manufacturing", BIO. IND., vol. 23, no. 9, 2006, pages 26 - 34, XP003021904
STEHLE, P. ET AL.: "In vivo utilization of cysteine-containing synthetic short-chain peptides after intravenous bolus injection in the rat.", J. NUTR., vol. 118, no. 12, 1988, pages 1470 - 1474
SUKUMAR, N. ET AL.: "Crystal structure and conformation of N-(t-butoxycarbonyl)-L-alanyl- S-benzyl-L-cysteine methyl ester.", BULL. CHEM. SOC. JPN., vol. 67, no. 7, 1994, pages 1976 - 1979
STEHLE, P. ET AL.: "In vivo utilization of cysteine-containing synthetic short-chain peptides after intravenous bolus injection in the rat.", J. NUTR., vol. 118, no. 12, 1988, pages 1470 - 1474
SUKUMAR, N. ET AL.: "Crystal structure and conformation of N-(t-butoxycarbonyl)-L-alanyl- S-benzyl-L-cysteine methyl ester.", BULL. CHEM. SOC. JPN., vol. 67, no. 7, 1994, pages 1976 - 1979
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