Title:
CRYSTAL OF PYRIDO[3, 4-D]PYRIMIDINE DERIVATIVE OR SOLVATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/097295
Kind Code:
A1
Abstract:
Provided is a crystal of a novel pyrido[3, 4-d]pyrimidine derivative having excellent CDK 4/6 inhibitory activity. A crystal of a compound represented by formula (I). In the formula, R1 represents a hydrogen atom or a C1-3 alkyl group; R2 represents a hydrogen atom or an oxo group; L represents a single bond or a C1-3 alkylene group; and X represents CH or N.
Inventors:
MIYAMOTO HIDETOSHI (JP)
MIZUNO TSUYOSHI (JP)
UNOKI GEN (JP)
MIYAZAWA YUKI (JP)
YAJIMA NAOKI (JP)
MIZUNO TSUYOSHI (JP)
UNOKI GEN (JP)
MIYAZAWA YUKI (JP)
YAJIMA NAOKI (JP)
Application Number:
PCT/JP2017/042437
Publication Date:
May 31, 2018
Filing Date:
November 27, 2017
Export Citation:
Assignee:
TEIJIN PHARMA LTD (JP)
International Classes:
C07D471/04; A61K31/519; A61P9/10; A61P11/00; A61P29/00; A61P35/00; A61P43/00
Domestic Patent References:
| WO2016194831A1 | 2016-12-08 | |||
| WO2003062236A1 | 2003-07-31 | |||
| WO2010020675A1 | 2010-02-25 |
Foreign References:
| JP2006516561A | 2006-07-06 | |||
| JP2016530274A | 2016-09-29 |
Other References:
TANIGUCHI, K ET AL., NATURE MEDICINE, vol. 5, 1999, pages 760 - 767
NONOMURA Y ET AL., ARTHRITIS & RHEUMATOLOGY, vol. 54, no. 7, July 2006 (2006-07-01), pages 2074 - 83
AMERICAN JOURNAL PHYSIOLOGY: LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, vol. 286, 2004, pages L727 - L733
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 97, 2000, pages 10254 - 10259
SCIENCE, vol. 254, 1991, pages 1138 - 1146
GUHA M, NATURE BIOTECHNOLOGY, vol. 31, no. 3, March 2013 (2013-03-01), pages 187
JOURNAL OF CLINICAL INVESTIGATION, vol. 120, no. 7, 2010, pages 2528 - 2536
See also references of EP 3546456A4
NONOMURA Y ET AL., ARTHRITIS & RHEUMATOLOGY, vol. 54, no. 7, July 2006 (2006-07-01), pages 2074 - 83
AMERICAN JOURNAL PHYSIOLOGY: LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, vol. 286, 2004, pages L727 - L733
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 97, 2000, pages 10254 - 10259
SCIENCE, vol. 254, 1991, pages 1138 - 1146
GUHA M, NATURE BIOTECHNOLOGY, vol. 31, no. 3, March 2013 (2013-03-01), pages 187
JOURNAL OF CLINICAL INVESTIGATION, vol. 120, no. 7, 2010, pages 2528 - 2536
See also references of EP 3546456A4
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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