CRYSTAL OF PYRROLIDYLTHIOCARBAPENEM DERIVATIVE, LYOPHILIZED PREPARATION CONTAINING SAID CRYSTAL, AND PROCESS FOR PRODUCING THE SAME

Title:

CRYSTAL OF PYRROLIDYLTHIOCARBAPENEM DERIVATIVE, LYOPHILIZED PREPARATION CONTAINING SAID CRYSTAL, AND PROCESS FOR PRODUCING THE SAME

Document Type and Number:

WIPO Patent Application WO/1995/029913

Kind Code:

A1

Abstract:

Crystal of (1R, 5S, 6S)-6-[(1R)-1-hydroxyethyl]-2-[(3S, 5S)-5-sulfamoylaminomethyl-1-pyrrolidin-3-yl]thio-1-methyl-1-carba-2-penem-3-carboxylic acid represented by formula (I). The process for producing a lyophilized preparation containing the crystals involves the step of freezing an aqueous solution of the above compound by cooling to -20 �C or below, the step of warming the frozen solution to 0 to -10 �C, and the step of cooling and warming the solution at least twice in the temperature range of 0 to -10 �C.

Inventors:

INOUE MASAYOSHI (JP)
FUJIKANE KAZUICHI (JP)
SUGIYAMA KENJI (JP)
TAI HIDEAKI (JP)
MATSUBARA FUMIHIKO (JP)
ODA KATSUO (JP)
OYA TAKASHI (JP)
HAMADA YOSHINORI (JP)

Application Number:

PCT/JP1995/000858

Publication Date:

November 09, 1995

Filing Date:

April 28, 1995

Export Citation:

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Assignee:

SHIONOGI & CO (JP)
INOUE MASAYOSHI (JP)
FUJIKANE KAZUICHI (JP)
SUGIYAMA KENJI (JP)
TAI HIDEAKI (JP)
MATSUBARA FUMIHIKO (JP)
ODA KATSUO (JP)
OYA TAKASHI (JP)
HAMADA YOSHINORI (JP)

International Classes:

A61K9/19; C07D477/20; (IPC1-7): C07D477/20; A61K31/40; A61K9/19

Foreign References:

JPH05294970A	1993-11-09
JPS6479180A	1989-03-24
JPS61172878A	1986-08-04
JPS61129123A	1986-06-17
JPH0459730A	1992-02-26

Other References: