Title:
CRYSTAL OF PYRROLOQUINOLINEQUINONE DISODIUM SALT, AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2012/173217
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a novel pyrroloquinolinequinone disodium crystal having excellent dispersibility in solvents and excellent permeability through the skin; and a method for producing the pyrroloquinolinequinone disodium crystal with high efficiency. The present invention provides: a novel pyrroloquinolinequinone disodium crystal which is produced by drying a crystal produced under specified conditions by a drying means such as lyophilization, ambient drying and vacuum drying; and a method for producing the pyrroloquinolinequinone disodium crystal.
Inventors:
IKEMOTO KAZUTO (JP)
SAKAMOTO HITOSHI (JP)
SAKAMOTO HITOSHI (JP)
Application Number:
PCT/JP2012/065303
Publication Date:
December 20, 2012
Filing Date:
June 15, 2012
Export Citation:
Assignee:
MITSUBISHI GAS CHEMICAL CO (JP)
IKEMOTO KAZUTO (JP)
SAKAMOTO HITOSHI (JP)
IKEMOTO KAZUTO (JP)
SAKAMOTO HITOSHI (JP)
International Classes:
C07D471/04; C12P7/66; A61K31/4745; A61P1/16; A61P17/02; A61P27/12; A61P35/00; A61P37/08; A61P43/00
Domestic Patent References:
| WO2011007633A1 | 2011-01-20 | |||
| WO2011055796A1 | 2011-05-12 | |||
| WO2011007633A1 | 2011-01-20 |
Foreign References:
| JPS62246575A | 1987-10-27 | |||
| JPH0267284A | 1990-03-07 | |||
| JP2005530786A | 2005-10-13 | |||
| JP2011246442A | 2011-12-08 | |||
| JP2007269769A | 2007-10-18 | |||
| JPH07113024A | 1995-05-02 | |||
| JP2751183B2 | 1998-05-18 |
Other References:
ISHIDA, T. ET AL.: "Molecular and Crystal Structure of PQQ (Methoxatin), a Novel Coenzyme of Quinoproteins: Extensive Stacking Character and Metal Ion Interaction", J. AM. CHEM. SOC., vol. 111, 1989, pages 6822 - 6828, XP008149475
ISHIDA, T. ET AL.: "Molecular and crystal structure of PQQ(methoxatin), a novel coenzyme of quinoproteins: extensive stacking character and metal ion interaction", JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 111, 1989, pages 6822 - 6828, XP008149475, DOI: doi:10.1021/ja00199a050
ISHIDA, T. ET AL.: "Molecular and crystal structure of PQQ(methoxatin), a novel coenzyme of quinoproteins: extensive stacking character and metal ion interaction", JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 111, 1989, pages 6822 - 6828, XP008149475, DOI: doi:10.1021/ja00199a050
Attorney, Agent or Firm:
KATSUNUMA Hirohito et al. (JP)
Katsunuma Hirohito (JP)
Katsunuma Hirohito (JP)
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Claims: