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Title:
CRYSTAL OF REDUCED-FORM GLUTATHIONE AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2017/159555
Kind Code:
A1
Abstract:
The purpose of the invention is to provide: a crystal of reduced-form glutathione in which the content of impurities, particularly L-cysteinyl-L-glycine, is reduced; and a method for producing the same. The invention relates to a crystal of reduced-form glutathione wherein, in high-performance liquid chromatography (HPLC) analysis, the peak area of L-cysteinyl-L-glycine is 0.02 or less with respect to a peak area of 100 of the reduced-form glutathione.

Inventors:
FUKUMOTO KAZUNARI (JP)
IGUCHI MAYA (JP)
NAGANO HIROSHI (JP)
Application Number:
PCT/JP2017/009660
Publication Date:
September 21, 2017
Filing Date:
March 10, 2017
Export Citation:
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Assignee:
KYOWA HAKKO BIO CO LTD (JP)
International Classes:
C07K5/037; A61P1/16; A61P39/02; A61K38/06
Domestic Patent References:
WO2008126784A12008-10-23
WO2011132724A12011-10-27
WO2012137824A12012-10-11
WO2010140625A12010-12-09
WO2014133129A12014-09-04
WO2011137824A12011-11-10
Foreign References:
JPS60258199A1985-12-20
JPS52131528A1977-11-04
JPS44239B
JPS454755B
JPS462838B
JPS4527797B
JPS61282397A1986-12-12
JPS60105499A1985-06-10
JPS5243963B21977-11-04
Other References:
APPL. MICROBIOL. BIOTECHNOL., vol. 66, 2004, pages 233
J. INVESTIG. MED., vol. 47, no. 3, 1999, pages 151 - 160
BIOFACTORS., vol. 17, 2003, pages 187 - 198
MICROBIOL. BIOTECHNOL., vol. 66, 2004, pages 233
See also references of EP 3431488A4
Attorney, Agent or Firm:
EIKOH PATENT FIRM, P.C. (JP)
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