Title:
CRYSTAL STRUCTURE OF SURVIVIN
Document Type and Number:
WIPO Patent Application WO2002002622
Kind Code:
A3
Abstract:
Provided is the structure of an inhibitor of apoptosis protein (IAP). ANGSTROM 2.58 A crystal structure of a human survivin point mutant (L54M) determined by Multiple Wavelength Anomalous Dispersion (MAD) using the endogenously bound Zn+2 ions is provided. Methods of using the crystal structure and atomic coordinates fo the development of IAP binding agents is also provided. In addition, the disclosure provides computer programs on computer readable medium for use in developing iAP binding agents.
Inventors:
NOEL JOSEPH P (US)
VERDACIA MARK (US)
HUNTER TONY (US)
HUANG HAN-KUEI (US)
VERDACIA MARK (US)
HUNTER TONY (US)
HUANG HAN-KUEI (US)
Application Number:
PCT/US2001/020872
Publication Date:
September 12, 2002
Filing Date:
June 29, 2001
Export Citation:
Assignee:
SALK INST FOR BIOLOGICAL STUDI (US)
NOEL JOSEPH P (US)
VERDACIA MARK (US)
HUNTER TONY (US)
HUANG HAN-KUEI (US)
NOEL JOSEPH P (US)
VERDACIA MARK (US)
HUNTER TONY (US)
HUANG HAN-KUEI (US)
International Classes:
C07K14/47; (IPC1-7): G01N33/68; A61K39/395; C07K14/47; C07K16/18; C30B29/58
Domestic Patent References:
| WO1998022589A2 | 1998-05-28 |
Other References:
HINDS MARK G ET AL: "Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat.", NATURE STRUCTURAL BIOLOGY, vol. 6, no. 7, July 1999 (1999-07-01), pages 648 - 651, XP008004532, ISSN: 1072-8368
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; May 2000 (2000-05-01), ITO TAKESHI ET AL: "Survivin promotes cell proliferation in human hepatocellular carcinoma.", XP002201893, Database accession no. PREV200000239207
DOUBLIE S: "PREPARATION OF SELENOMETHIONYL PROTEINS FOR PHASE DETERMINATION", METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC, SAN DIEGO, CA, US, no. 276, 1997, pages 523 - 530, XP001053309, ISSN: 0076-6879
KUNTZ I D ET AL: "STRUCTURE-BASED MOLECULAR DESIGN", ACCOUNTS OF CHEMICAL RESEARCH, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 27, no. 5, May 1994 (1994-05-01), pages 117 - 123, XP000885741, ISSN: 0001-4842
DEVERAUX QUINN L ET AL: "IAP family proteins: Suppressors of apoptosis", GENES AND DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, NEW YORK, US, vol. 13, no. 3, 1 February 1999 (1999-02-01), pages 239 - 252, XP002175394, ISSN: 0890-9369
VERDECIA MARK A ET AL: "Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement.", NATURE STRUCTURAL BIOLOGY, vol. 7, no. 7, July 2000 (2000-07-01), pages 602 - 608, XP002201890, ISSN: 1072-8368
MUCHMORE STEVEN W ET AL: "Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin.", MOLECULAR CELL, vol. 6, no. 1, July 2000 (2000-07-01), pages 173 - 182, XP002201891, ISSN: 1097-2765
CHANTALAT LAURENT ET AL: "Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions.", MOLECULAR CELL, vol. 6, no. 1, July 2000 (2000-07-01), pages 183 - 189, XP002201892, ISSN: 1097-2765
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; May 2000 (2000-05-01), ITO TAKESHI ET AL: "Survivin promotes cell proliferation in human hepatocellular carcinoma.", XP002201893, Database accession no. PREV200000239207
DOUBLIE S: "PREPARATION OF SELENOMETHIONYL PROTEINS FOR PHASE DETERMINATION", METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC, SAN DIEGO, CA, US, no. 276, 1997, pages 523 - 530, XP001053309, ISSN: 0076-6879
KUNTZ I D ET AL: "STRUCTURE-BASED MOLECULAR DESIGN", ACCOUNTS OF CHEMICAL RESEARCH, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 27, no. 5, May 1994 (1994-05-01), pages 117 - 123, XP000885741, ISSN: 0001-4842
DEVERAUX QUINN L ET AL: "IAP family proteins: Suppressors of apoptosis", GENES AND DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, NEW YORK, US, vol. 13, no. 3, 1 February 1999 (1999-02-01), pages 239 - 252, XP002175394, ISSN: 0890-9369
VERDECIA MARK A ET AL: "Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement.", NATURE STRUCTURAL BIOLOGY, vol. 7, no. 7, July 2000 (2000-07-01), pages 602 - 608, XP002201890, ISSN: 1072-8368
MUCHMORE STEVEN W ET AL: "Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin.", MOLECULAR CELL, vol. 6, no. 1, July 2000 (2000-07-01), pages 173 - 182, XP002201891, ISSN: 1097-2765
CHANTALAT LAURENT ET AL: "Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions.", MOLECULAR CELL, vol. 6, no. 1, July 2000 (2000-07-01), pages 183 - 189, XP002201892, ISSN: 1097-2765
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