Title:
CRYSTAL TYPE II SUBSTANCE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/227429
Kind Code:
A1
Abstract:
Provided are a crystal type II substance of a compound A (chemical name:1-piperazine dithioformate-3-cyano-3,3-diphenylpropyl ester hydrochloride, a preparation method therefor, and pharmaceutical composition and application thereof in preparation of medicines for treating and preventing tumors.
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Inventors:
LI RUNTAO (CN)
LV YANG (CN)
CUI JINGRONG (CN)
DU GUANHUA (CN)
GE ZEMEI (CN)
YANG SHIYING (CN)
LV YANG (CN)
CUI JINGRONG (CN)
DU GUANHUA (CN)
GE ZEMEI (CN)
YANG SHIYING (CN)
Application Number:
PCT/CN2017/088251
Publication Date:
December 20, 2018
Filing Date:
June 14, 2017
Export Citation:
Assignee:
UNIV BEIJING (CN)
International Classes:
C07D295/21; A61K31/495; A61P35/00
Foreign References:
| CN107200720A | 2017-09-26 | |||
| CN1328999A | 2002-01-02 |
Other References:
JIN, RIXIAN ET AL.: "Preparation and rats; pharmacokinetics of TM208 HP-beta-CD inclusion complexes", CHINESE JOURNAL OF NEW DRUGS, vol. 15, no. 16, 31 December 2006 (2006-12-31), pages 1370 - 1373
HOU, X. ET AL.: "Synthesis and structure-activity relationships of a novel class of dithiocarbamic acid esters as anticancer agent", ARCH PHARM (WEINHEIM)., vol. 344, no. 5, May 2011 (2011-05-01), pages 320 - 332, XP055554612, DOI: 10.1002/ardp.201000259
HOU, X. ET AL.: "Synthesis and structure-activity relationships of a novel class of dithiocarbamic acid esters as anticancer agent", ARCH PHARM (WEINHEIM)., vol. 344, no. 5, May 2011 (2011-05-01), pages 320 - 332, XP055554612, DOI: 10.1002/ardp.201000259
Attorney, Agent or Firm:
BEIJING SUNHOPE INTELLECTUAL PROPERTY LTD. (CN)
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