Title:
CRYSTAL
Document Type and Number:
WIPO Patent Application WO/2019/065792
Kind Code:
A1
Abstract:
The main purpose of the present invention is to provide a novel crystal of 2-{4-[N-(5,6-diphenylpyrazine-2-yl)-N-isopropylamino]butyloxy} acetic acid (hereinafter "compound B"). A type I crystal of compound B with which, in a powder X-ray diffraction spectrum obtained by using CuKα radiation (λ=1.54 Å), the diffraction angle (2θ) shows peaks at the diffraction angles 6.4°, 8.1°, 9.5°, 10.9°, 13.2°, 15.7°, 17.0°, 19.5°, 20.3°, 21.0°, and 22.8°. A type II crystal of compound B with which, in a powder X-ray diffraction spectrum obtained by using CuKα radiation (λ=1.54 Å), the diffraction angle (2θ) shows peaks at the diffraction angles 9.6°, 11.4°, 11.7°, 16.3°, 17.5°, 18.5°, 18.7°, 19.9°, 20.1°, 21.0°, and 24.6°.
Inventors:
FUJIWARA TOSHIO (US)
Application Number:
PCT/JP2018/035828
Publication Date:
April 04, 2019
Filing Date:
September 27, 2018
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD (JP)
International Classes:
C07D241/20; A61K31/4965; A61P1/04; A61P7/02; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P11/14; A61P13/12; A61P17/02; A61P25/00; A61P43/00
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See also references of EP 3689854A4
SHIOJI, YUSAKU: "Passage [Manufacture technology of solid tablet]", MANUFACTURE TECHNOLOGY OF SOLID TABLET, 27 January 2003 (2003-01-27), pages 9 - 14, XP009519792, ISBN: 4-88231-783-4
HIRAYAMA, NORIAKI: "Passage, Chapter 3 & 4; Organic compound crystal preparation handbook - principle and knowhow", ORGANIC COMPOUND CRYSTAL PREPARATION HANDBOOK - PRINCIPLE AND KNOWHOW, 25 July 2008 (2008-07-25), pages 37 - 84, XP009519818, ISBN: 978-4-621-07991-1
HEPATOLOGY, vol. 45, no. 1, 2007, pages 159 - 169
PUBMED: NIHON YAKURIGAKU ZASSHI, vol. 117, no. 2, 2001, pages 123 - 130
INTERNATIONAL ANGIOLOGY, vol. 2, 2010, pages 49 - 54
JAPANESE JOURNAL OF CLINICAL IMMUNOLOGY, vol. 16, no. 5, 1993, pages 409 - 414
JAPANESE JOURNAL OF THROMBOSIS AND HEMOSTASIS, vol. 1, no. 2, 1990, pages 94 - 105
THE JOURNAL OF RHEUMATOLOGY, vol. 36, no. 10, 2009, pages 2244 - 2249
THE JAPANESE JOURNAL OF PHARMACOLOGY, vol. 43, no. 1, 1987, pages 81 - 90
BRITISH HEART JOURNAL, vol. 53, no. 2, 1985, pages 173 - 179
THE LANCET, vol. 1, no. 4880, 1981, pages 569 - 572
EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 449, 2002, pages 167 - 176
THE JOURNAL OF CLINICAL INVESTIGATION, vol. 117, 2007, pages 464 - 72
AMERICAN JOURNAL OF PHYSIOLOGY LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, vol. 296, 2009, pages L648 - L656
See also references of EP 3689854A4
Attorney, Agent or Firm:
NAKAMURA Ayatsugu (JP)
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