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Patent Searching and Data


Title:
CRYSTALLINE CEFOPERAZONE INTERMEDIATE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/175587
Kind Code:
A3
Abstract:
The present invention relates to a crystalline form of an intermediate for cefoperazone of formula (1 ) and to a process for the preparation thereof by enzymatic condensation of a 3'-thiosubstituted β-lactam nucleus with a phenylglycine derivative.

Inventors:
MOODY HAROLD MONRO (NL)
CUSAN CLAUDIA (NL)
IJPEIJ EDWIN GERARD (NL)
Application Number:
PCT/EP2012/061912
Publication Date:
March 28, 2013
Filing Date:
June 21, 2012
Export Citation:
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Assignee:
DSM SINOCHEM PHARM NL BV (NL)
MOODY HAROLD MONRO (NL)
CUSAN CLAUDIA (NL)
IJPEIJ EDWIN GERARD (NL)
International Classes:
C12P35/04; A61K31/545; C07D501/24; A61P31/04
Foreign References:
US3946003A1976-03-23
EP0523585A21993-01-20
EP1394262A12004-03-03
Other References:
DUNN G L ET AL: "Orally active 7-phenylglycyl cephalosporins. Structure-activity studies related to cefatrizine (SK & F 60771)", JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION, TOKYO, JP, vol. 29, no. 1, 1 January 1976 (1976-01-01), pages 65 - 80, XP008157551, ISSN: 0021-8820
CAIRA M R: "CRYSTALLINE POLYMORPHISM OF ORGANIC COMPOUNDS", TOPICS IN CURRENT CHEMISTRY, SPRINGER, BERLIN, DE, vol. 198, 1 January 1998 (1998-01-01), pages 163 - 208, XP001156954, ISSN: 0340-1022, ISBN: 978-3-540-36760-4, DOI: 10.1007/3-540-69178-2_5
Attorney, Agent or Firm:
VROOM, DE, Erik et al. (P.O. Box 130, AC Echt, NL)
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