Title:
CRYSTALLINE CEPHALOSPORIN COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND INTERMEDIATES FOR THEIR PREPARATION
Document Type and Number:
WIPO Patent Application WO/1988/010263
Kind Code:
A1
Abstract:
Stable crystalline sulfate of (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxyimino)-acetamido]-3-(5,6-dihydroxy-2-methyl-2-isoindolinium)-methyl-3-cephem-4-carboxylate and its hydrate, process for their preparation, and starting materials useful for preparing these compounds, i.e., hydrochloride of (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methyl-ethoxyimino)acetamido]-3-(5,6-dihydroxy-2-methyl-2-isoindolinium)methyl-3-cephem-4-carboxylate and its hydrate are disclosed.
Inventors:
NAKAGAWA SUSUMU (JP)
USHIJIMA RYOSUKE (JP)
NAKANO FUMIO (JP)
YAMADA KOJI (JP)
MANO EIICHI (JP)
USHIJIMA RYOSUKE (JP)
NAKANO FUMIO (JP)
YAMADA KOJI (JP)
MANO EIICHI (JP)
Application Number:
PCT/JP1987/000417
Publication Date:
December 29, 1988
Filing Date:
June 25, 1987
Export Citation:
Assignee:
BANYU PHARMA CO LTD (JP)
International Classes:
A61K31/545; C07D501/46; (IPC1-7): C07D501/46
Foreign References:
| JPS61267587A | 1986-11-27 | |||
| JPS61215689A | 1986-09-25 | |||
| JPH0613793A | 1994-01-21 | |||
| JPS62103090A | 1987-05-13 |
Other References:
See also references of EP 0321562A4
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