CRYSTALLINE FORM OF 2-(2-HYDROXY PHENYL)BENZ[E][1,3]OXAZIN-4-ONE, PROCESS FOR THE SAME AND USE FOR PRODUCING 4-(3,5-BIS(2-HYDROXYPHENYL)-1H-1,2,4-TRIAZOL-1-YL)BENZOIC ACID

WIPO Patent Application WO/2010/023685

A3

The present invention relates to a crystalline form of 2-(2-hydroxyphenyl) benz [e] [1, 3] oxazin-4-one, a process for production thereof and its use in the preparation of 4- (3, 5-bis (2-hydroxyphenyl)-1H-1, 2, 4-triazol-1-yl) benzoic acid. The improved process for the preparation 4-(3,5-bis (2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl) benzoic acid (Deferasirox), wherein salicylic chloride is reacted with salicylamide in presence of a solvent to give acyl compound, which is heated to higher temperature in-situ to undergo cyclization to obtain crystalline form of 2-(2-hydroxyphenyl) benz [e] [1, 3] oxazin-4-on and further reaction with hydrazino benzoic acid to give 4-(3,5- bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl)benzoic acid.

KARUSALA NAGESWARA RAO (IN)
CHAVHAN BHAUSAHEB SHRIRANG (IN)
GOSULA VEERA VENKATA SATYA SURYA APPALA NARASIMHA (IN)
DATTA DEBASHISH (IN)

PCT/IN2009/000461

August 19, 2010

August 20, 2009

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MATRIX LAB LTD (IN)
KARUSALA NAGESWARA RAO (IN)
CHAVHAN BHAUSAHEB SHRIRANG (IN)
GOSULA VEERA VENKATA SATYA SURYA APPALA NARASIMHA (IN)
DATTA DEBASHISH (IN)

C07D265/22; C07D249/08

WO2003053986A1	2003-07-03
WO2009094956A1	2009-08-06
WO2009130604A2	2009-10-29
WO2009147529A1	2009-12-10

STEINHAUSER, S. ET AL.: "Complex Formation of ICL670 and Related Ligands with Fe(III) and Fe(II).", EUR. J. INORG. CHEM., 2004, pages 4177 - 4192

BABU, Ramesh, M., R. (709/710 Tolstoy House15-17 Tolstoy Marg, New Delhi 1, IN)

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